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Previous Volume 338:991-992 April 2, 1998 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: TNP-470 is a new inhibitor of angiogenesis that has shown potent antitumor activity in preclinical studies.^1,2,3,4 We performed a phase 1 study of this drug in patients with advanced squamous-cell carcinoma of the uterine cervix.⁵ One of the patients in the study was a 49-year-old woman who had presented in 1992 with stage IIIA, poorly differentiated squamous-cell carcinoma of the cervix. She was treated with a combination of external and intracavitary radiation therapy. The side effects of this treatment included recurrent episodes of small-bowel obstruction, requiring surgical exploration and intestinal resection. Pathological examinations of multiple biopsy specimens . . . [Full Text of this Article]

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