In 1969, McCully made the clinical observation linking elevatedplasma homocyst(e)ine concentrations with vascular disease.1He reported autopsy evidence of extensive arterial thrombosisand atherosclerosis in two children with elevated plasma homocyst(e)ineconcentrations and homocystinuria. On the basis of this observation,he proposed that elevated plasma homocyst(e)ine (hyperhomocyst(e)inemia)can cause atherosclerotic vascular disease. The term "homocyst(e)ine"is used to define the combined pool of homocysteine, homocystine,mixed disulfides involving homocysteine, and homocysteine thiolactonefound in the plasma of patients with hyperhomocyst(e)inemia.
Subsequent investigations have confirmed McCully's hypothesis,and it has recently become clear that hyperhomocyst(e)inemiais an independent risk factor . . . [Full Text of this Article]
Association between Hyperhomocyst(e)inemia and Atherosclerosis
Treatment of Hyperhomocyst(e)inemia
Pathophysiologic Mechanisms of Hyperhomocyst(e)inemia
Conclusions
Source Information
From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany St., W-507, Boston, MA 02118, where reprint requests should be addressed to Dr. Loscalzo.
References
Related Letters:
Homocyst(e)ine and Atherothrombosis
Lawson M. F., van Guldener C., Donker A. J.M., Stehouwer C. D.A., Nath K. A., Welch G. N., Loscalzo J.
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N Engl J Med 1998;
339:477-479, Aug 13, 1998.
Correspondence
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A correction has been published: N Engl J Med 1998;339(7):477.
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