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Correspondence
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Volume 338:1071-1073 April 9, 1998 Number 15
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Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma

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 by Drazen, J. M.
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 by Pauwels, R. A.
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To the Editor: Pauwels et al. (Nov. 13 issue)1 found that in patients with persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonide therapy or the use of a higher dose of budesonide may be beneficial. Three features of the study design may have helped increase the size of the effect seen and reduce its generalizability to clinical practice. First, the high rate of exacerbations of asthma in the group given low-dose budesonide is not surprising. In this group, the mean dose of inhaled corticosteroids was similar to that in the other groups (range, . . . [Full Text of this Article]

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