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Editorial
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Volume 338:1148-1150 April 16, 1998 Number 16
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Thrombolysis for Acute Arterial Occlusion of the Legs

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 by Ouriel, K.
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Since the initial clinical description by Tillett and associates1 more than 40 years ago, thrombolytic therapy has been hovering on the outskirts of medical practice. Despite intense interest by the pharmaceutical industry and a plethora of anecdotal clinical reports, thrombolysis has found a generally accepted role only in the treatment of acute coronary thrombosis. The treatment of ischemic stroke within a few hours after onset may be another indication,2 although this use of thrombolytic therapy is still being investigated.

To date, no convincing evidence has demonstrated the superiority of thrombolytic therapy over conventional therapy for venous thromboembolism or peripheral arterial . . . [Full Text of this Article]

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Related Letters:

A Comparison of Recombinant Urokinase with Vascular Surgery for Acute Arterial Occlusion of the Legs
Zarins C. K., Gurewich V., Ouriel K., Porter J. M.
Extract | Full Text  
N Engl J Med 1998; 339:564-565, Aug 20, 1998. Correspondence

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