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Case Records of the Massachusetts General Hospital
Weekly Clinicopathological Exercises
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Volume 338:1293-1301 April 30, 1998 Number 18
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Case 14-1998— A 49-Year-Old Woman with Primary Biliary Cirrhosis, Pulmonary Opacities, and a Pleural Effusion
John J. Reilly, and Eugene J. Mark

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Presentation of Case

A 49-year-old woman was admitted to the hospital because of interstitial lung disease.

She had a 13-year history of biopsy-confirmed primary biliary cirrhosis, with a positive test for antimitochondrial antibodies. She was treated initially with colchicine; ursodiol was later substituted. For six years, she had had a scleroderma-like illness characterized by mild sclerodactyly and hyperpigmented, tight skin on the arms and trunk, with Raynaud's phenomenon. The patient took quinapril and hydrochlorothiazide for hypertension and levothyroxine for hypothyroidism.

The patient worked in a clerical capacity. She had smoked one to two packs of cigarettes daily for 25 years but stopped 7 . . . [Full Text of this Article]

Differential Diagnosis

Clinical Diagnoses

Dr. John J. Reilly, Jr.'s, Diagnoses

Pathological Discussion

Anatomical Diagnosis

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