Antibodies to DNA are of interest to a broad spectrum of physiciansand other scientists. The presence of large amounts of serumantibodies to double-stranded DNA is specific for systemic lupuserythematosus, and some subgroups of these antibodies are pathogenic.It is likely that people are predisposed to have systemic lupuserythematosus if they can make pathogenic subgroups of antibodiesto DNA and if they cannot down-regulate them appropriately.Studies of patients with systemic lupus erythematosus and ofmurine models of the disease have provided information regardingthe different types of antibodies to DNA, their role in pathogenesis,and new . . . [Full Text of this Article]
Different Types of Antibodies to DNA
Tests for Antibodies to DNA
Clinical Applications of Tests for Antibodies to Double-Stranded DNA
Origin of Antibodies to DNA
Structure of Antibodies to DNA
The Role of Antibodies to DNA in the Pathogenesis of Disease
Regulation of Production of Antibodies to DNA
Experimental Therapies for Systemic Lupus Erythematosus That Regulate the Production of Antibodies to DNA
Conclusions
Source Information
From the Division of Rheumatology, Department of Medicine, University of California, Los Angeles, 32-48 Rehabilitation Center, 1000 Veteran Ave., Los Angeles, CA 90095-1670, where reprint requests should be addressed to Dr. Hahn.
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