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Review Article
Mechanisms of Disease
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Volume 338:1359-1368 May 7, 1998 Number 19
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Antibodies to DNA
Bevra Hannahs Hahn, M.D.

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Antibodies to DNA are of interest to a broad spectrum of physicians and other scientists. The presence of large amounts of serum antibodies to double-stranded DNA is specific for systemic lupus erythematosus, and some subgroups of these antibodies are pathogenic. It is likely that people are predisposed to have systemic lupus erythematosus if they can make pathogenic subgroups of antibodies to DNA and if they cannot down-regulate them appropriately. Studies of patients with systemic lupus erythematosus and of murine models of the disease have provided information regarding the different types of antibodies to DNA, their role in pathogenesis, and new . . . [Full Text of this Article]

Different Types of Antibodies to DNA

Tests for Antibodies to DNA

Clinical Applications of Tests for Antibodies to Double-Stranded DNA

Origin of Antibodies to DNA

Structure of Antibodies to DNA

The Role of Antibodies to DNA in the Pathogenesis of Disease

Regulation of Production of Antibodies to DNA

Experimental Therapies for Systemic Lupus Erythematosus That Regulate the Production of Antibodies to DNA

Conclusions


Source Information

From the Division of Rheumatology, Department of Medicine, University of California, Los Angeles, 32-48 Rehabilitation Center, 1000 Veteran Ave., Los Angeles, CA 90095-1670, where reprint requests should be addressed to Dr. Hahn.

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