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Previous Volume 338:1475-1476 May 14, 1998 Number 20 Next

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By David Healy. 317 pp. Cambridge, Mass., Harvard University Press, 1997. $39.95. ISBN 0-674-03957-2.

Major depression is increasingly recognized as a worldwide cause of morbidity, mortality, and health expenditure. A study by the World Health Organization and Harvard University estimates that major depression is currently the fourth leading cause of disability worldwide. An epidemiologic study of more than 40,000 people found consistent core symptoms and a youthful age at onset in 10 diverse countries. A committee of geneticists convened in 1997 by the National Institute of Mental Health (NIMH) concluded that there was sufficient evidence of a genetic basis to support funding large-scale molecular studies of early-onset major depression. Yet David Healy's scholarly and . . . [Full Text of this Article]

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