FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 338:1537-1538 May 21, 1998 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Aaltonen, L. A. PubMed Citation

The recent discovery of the genetic basis of certain familial aggregations of colorectal cancer validated 90 years of clinical observation suggesting that such aggregations are hereditary.¹ It also promised the ability to detect asymptomatic carriers of the deleterious genes, with attendant gains in the control of cancer. Our ability to act on that promise has been held back by the need for answers to two difficult questions: How common are the mutations of interest, and who should be tested for them? The work of Aaltonen et al.,² reported in this issue of the Journal, provides some valuable answers.

Germ-line mutations . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Chao, E. C., Lipkin, S. M. (2006). Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis. Nucleic Acids Res 34: 840-852 [Abstract] [Full Text]  
• Roy, H. K., Olusola, B. F., Clemens, D. L., Karolski, W. J., Ratashak, A., Lynch, H. T., Smyrk, T. C. (2002). AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 23: 201-205 [Abstract] [Full Text]  
• Raedle, J., Trojan, J., Brieger, A., Weber, N., Schafer, D., Plotz, G., Staib-Sebler, E., Kriener, S., Lorenz, M., Zeuzem, S. (2001). Bethesda Guidelines: Relation to Microsatellite Instability and MLH1 Promoter Methylation in Patients with Colorectal Cancer. ANN INTERN MED 135: 566-576 [Abstract] [Full Text]  
• Lynch, H. T., Lynch, J. (2000). Lynch Syndrome: Genetics, Natural History, Genetic Counseling, and Prevention. JCO 18: 19s-31 [Abstract] [Full Text]  
• MONTERA, M., RESTA, N., SIMONE, C., GUANTI, G., MARCHESE, C., CIVITELLI, S., MANCINI, A., POZZI, S., DE SALVO, L., BRUZZONE, D., DONADINI, A., ROMIO, L., MARENI, C. (2000). Mutational germline analysis of hMSH2 and hMLH1 genes in early onset colorectal cancer patients. J. Med. Genet. 37: 7e-7 [Full Text]  
• Salovaara, R., Loukola, A., Kristo, P., Kaariainen, H., Ahtola, H., Eskelinen, M., Harkonen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J., Valkamo, E., Jarvinen, H., Mecklin, J.-P., Aaltonen, L. A., de la Chapelle, A. (2000). Population-Based Molecular Detection of Hereditary Nonpolyposis Colorectal Cancer. JCO 18: 2193-2200 [Abstract] [Full Text]  
• Loukola, A., Salovaara, R., Kristo, P., Moisio, A.-L., Kaariainen, H., Ahtola, H., Eskelinen, M., Harkonen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J., Valkamo, E., Jarvinen, H., Mecklin, J.-P., de la Chapelle, A., Aaltonen, L. A. (1999). Microsatellite Instability in Adenomas as a Marker for Hereditary Nonpolyposis Colorectal Cancer. Am. J. Pathol. 155: 1849-1853 [Abstract] [Full Text]  
• Loukola, A., de la Chapelle, A., Aaltonen, L. A (1999). Strategies for screening for hereditary non-polyposis colorectal cancer. J. Med. Genet. 36: 819-822 [Abstract] [Full Text]  
• Syngal, S., Fox, E. A., Li, C., Dovidio, M., Eng, C., Kolodner, R. D., Garber, J. E. (1999). Interpretation of Genetic Test Results for Hereditary Nonpolyposis Colorectal Cancer: Implications for Clinical Predisposition Testing. JAMA 282: 247-253 [Abstract] [Full Text]  
• (1998). The Prevalence of Hereditary Nonpolyposis Colorectal Cancer. JWatch General 1998: 2-2 [Full Text]