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Previous Volume 338:1585-1590 May 28, 1998 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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DNA sequences of human herpesvirus 8 (HHV-8) have been detected in all forms of Kaposi's sarcoma.^1,2,3 HHV-8 has also been detected in primary effusion lymphomas,⁴ Castleman's disease,⁵ and multiple myeloma⁶ and reported anecdotally in cases of angioimmunoblastic lymphadenopathy and germinal-center hyperplasia.⁷ Indirect immunofluorescence and immunoblot assays, based on antigens from a latently infected lymphoma cell line, have shown that HHV-8 is not a ubiquitous viral infection in humans. The overall seroprevalence of HHV-8 is less than 5 percent in the United States and United Kingdom, up to 35 percent in southern Italy, and over 50 percent in East Africa.^{8,9,10,11,12,13} Seroconversion . . . [Full Text of this Article]

Case Report

Methods

Histopathological, Immunohistochemical, and in Situ Hybridization Studies

Amplification and Southern Blotting

Serologic Tests for HHV-8

Results

Discussion

Source Information

From the Departments of Immunology and Hematology (E.O., J.-P.C.) and Pathology (D.C.-H.) and the Laboratories of Virology (V.B., F.A.) and Molecular Hematology (L.G., F.S.), Hôpital Saint-Louis, Paris; and the Department of Medical Microbiology and Genitourinary Medicine, University of Liverpool, Liverpool, United Kingdom (T.F.S., J.S.).

Address reprint requests to Dr. Oksenhendler at the Service d'Immuno-Hématologie, Hôpital Saint-Louis, 1 Ave. Claude Vellefaux, 75010 Paris, France.

References

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