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Previous Volume 338:1626-1629 May 28, 1998 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We respectfully disagree with Adrogué and Madias (Jan. 1 and Jan. 8 issues)¹ on a number of issues in their review of acid–base disturbances. The authors fail to emphasize that, except in specific circumstances, such as methanol or ethylene glycol poisoning, there is no scientific evidence to support treating a metabolic or respiratory acidosis with sodium bicarbonate. Furthermore, it is the intracellular pH that is important in determining cellular function.² The intracellular buffering system is much more effective than the extracellular buffers in restoring pH to normal.² Consequently, patients have tolerated a pH as low as 7.0 . . . [Full Text of this Article]

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