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The past decade has seen an explosion in our understanding of the allergic process. The immunologic pathways, cytokines, and inflammatory cells that participate in allergic diseases have all been subject to intense scrutiny. In parallel, an expanding pharmacopeia has become available to the practitioner who manages allergic diseases, and for the first time many agents are based on an understanding of specific inflammatory pathways in allergic disease. But, despite this increased understanding and the new pharmacologic agents, the worldwide epidemic of allergic disorders continues. This epidemic was first described with respect to asthma, but more recently an increased incidence of
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