Delayed Cerebellar Disease and Death after Accidental Exposure to Dimethylmercury
David W. Nierenberg, M.D., Richard E. Nordgren, M.D., Morris B. Chang, M.D., Richard W. Siegler, M.D., Michael B. Blayney, Ph.D., Fred Hochberg, M.D., Taft Y. Toribara, Ph.D., Elsa Cernichiari, M.S., and Thomas Clarkson, Ph.D.
Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
Ingestion of fish or grain contaminated with methylmercury resultedin epidemics of severe neurotoxicity and death in Japan in the1950s and 1960s1 and in Iraq in 1972.2 The World Health Organizationand other organizations have warned of the dangers of methylmercurycompounds to the environment and to scientific researchers.1,3,4,5,6Dimethylmercury may be even more dangerous than methylmercurycompounds. The physical properties of dimethylmercury permittransdermal absorption, and the volatility of this liquid permitstoxic exposure through inhalation. Since dimethylmercury islethal at a dose of approximately 400 mg of mercury (equivalentto a few drops, or about 5 mg . . . [Full Text of this Article]
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From the Section of Clinical Pharmacology, Departments of Medicine and Pharmacology/Toxicology (D.W.N.), the Section of Neurology, Departments of Medicine and Pediatrics (R.E.N., M.B.C.), and the Department of Pathology (R.W.S.), Dartmouth Medical School; and the Office of Environmental Health and Safety, Dartmouth College (M.B.B.) both in Hanover, N.H.; the Neurology Service, Massachusetts General Hospital, Boston (F.H.); and the Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, N.Y. (T.Y.T., E.C., T.C.).
Address reprint requests to Dr. Nierenberg at the DartmouthHitchcock Medical Center, Hinman Box 7506, Lebanon, NH 03756.
References
Related Letters:
Death after Exposure to Dimethylmercury
Byard R. W., Couper R., Lockwood A. H., Landrigan P. J., Hanlon D. P., Nierenberg D. W., Blayney M. B., Clarkson T. W.
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N Engl J Med 1998;
339:1243-1244, Oct 22, 1998.
Correspondence
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