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Previous Volume 338:1729-1732 June 11, 1998 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Normal pubertal development and fertility depend on the intricate interplay of hypothalamic, pituitary, and gonadal factors. Crucial in this respect are normal secretory patterns of follicle-stimulating hormone and luteinizing hormone. These hormones stimulate the production of estrogen and ovulation in women and the production of testosterone and spermatogenesis in men. Secreted from common gonadotroph cells, the hormones are heterodimers composed of a common -subunit and a specific -subunit, each encoded by a separate gene. Specificity of action depends on the recognition of these hormones by specific receptors on the surface of gonadal cells.

Various genetic defects of the hypothalamic–pituitary–gonadal axis . . . [Full Text of this Article]

Methods

Subjects

DNA Analysis

Results

Discussion

Source Information

From the Pediatric Diagnostic and Therapeutic Center (M.P., Y.S.), the Endocrine Clinic (J.E.A.), and the Genetic Institute (R.P.), Soroka Medical Center and Faculty of Health, Ben Gurion University of the Negev, Beer Sheva, Israel.

Address reprint requests to Prof. Phillip at Schneider Children's Medical Center of Israel, 14 Kaplan St., Petah-Tikva 49202, Israel.

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