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Previous Volume 338:1741-1751 June 11, 1998 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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A primary goal in organ transplantation is the prevention or effective treatment of infection, the most common life-threatening complication of long-term immunosuppressive therapy. The challenges involved in achieving this goal are several: a broad range of potential sources of infection ranging from latent viruses to pathogens of both community and hospital origin; immunosuppression-induced impairment of the inflammatory response, which attenuates the signs and symptoms of invasive infection; and the adverse effects of the antimicrobial drugs used for prophylaxis and therapy, which result both from the duration of therapy required and from interactions with the immunosuppressive drugs cyclosporine and tacrolimus. Our . . . [Full Text of this Article]

Risk of Infection in Transplant Recipients

Epidemiologic Exposure

The Net State of Immunosuppression

Timetable for Infection after Transplantation

Infection in the First Month after Transplantation

Infection One to Six Months after Transplantation

Infection More Than Six Months after Transplantation

Evaluation of the Donor and Recipient before Transplantation

Principles of Antimicrobial Therapy in Transplant Recipients

Strategies for Antimicrobial Therapy

            Prophylaxis

            Preemptive Therapy

Drug Toxicity in Transplant Recipients

Infections of Particular Importance in Transplant Recipients

CMV

EBV and Post-Transplantation Lymphoproliferative Disease

Fever and Pneumonitis

Central Nervous System Infection

Conclusions and Future Directions

Source Information

From the Program in Transplantation Infectious Disease, Massachusetts General Hospital, Boston (J.A.F., R.H.R.); Harvard Medical School, Boston (J.A.F.); and the Center for Experimental Pharmacology and Therapeutics, Division of Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Cambridge, Mass. (R.H.R.).

Address reprint requests to Dr. Rubin at the Program in Transplantation Infectious Disease, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114.

References

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Gómez-Moreno J., Cuervas-Mons V., Ridzon R., Onorato I. M., Palmer S. M., Tapson V. F., Stamm A. M., Fishman J. A., Rubin R. H.
Extract | Full Text  
N Engl J Med 1998; 339:1244-1246, Oct 22, 1998. Correspondence

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