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Volume 338:1775-1776 June 11, 1998 Number 24
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A Computer-Assisted Management Program for Antiinfective Agents

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by Kassirer, J. P.
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by Evans, R. S.
To the Editor: Evans et al. (Jan. 22 issue)1 have developed an innovative computer-assisted management program for antiinfective agents, but they have compared three groups that are not comparable: a group in which the recommendations of the computer-assisted management program were followed, a group in which recommendations were overridden, and all patients seen before the program was implemented. This is scientifically unsound. Selection bias could well account for any differences between groups. Equally likely explanations are differences between physicians who adhered to the program and those who did not or differences in the severity of disease. The failure to adjust . . . [Full Text of this Article]

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