Organ transplantation is now common. For patients with end-stagecardiac, hepatic, or pulmonary failure, it can be lifesaving.1For patients with diabetes mellitus, pancreatic transplantationoffers the chance of a cure and the arrest or reversal of diabeticcomplications such as neuropathy and retinopathy. In 1996 morethan 19,410 organ and tissue transplantations were performedin the United States, and 53,755 patients were on waiting listsfor transplantation.
Over the past two decades, the development of new immunosuppressivedrugs with improved efficacy and decreased toxicity has ledto substantial improvement in the survival of patients and inshort-term graft survival . . . [Full Text of this Article]
Role of T Cells in Transplant Rejection
Current Concepts in Immunosuppression
The Role of Costimulatory Signals in T-Cell Activation
T-Cell Costimulatory Blockade in Transplant Rejection
Acute Rejection
Chronic Rejection
Blockade of the CD40:CD40 Ligand Pathway
Preliminary Studies of Transplantation in Large Animals
Conclusions
Source Information
From the Laboratory of Immunogenetics and Transplantation, Renal Division, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (M.H.S.); and the Department of Medicine, University of Pennsylvania, Philadelphia (L.A.T.).
Address reprint requests to Dr. Turka at the University of Pennsylvania, 901 Stellar Chance Laboratories, 422 Curie Blvd., Philadelphia, PA 19104-6100.
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