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Correction to Greaves, N Engl J Med 338(7):478 February 12, 1998.

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Volume 338:1927 June 25, 1998 Number 26
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Ephedrine is Not Phenylephrine

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 by Greaves, M. W.
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 by Greaves, M. W.
To the Editor: In his review of Dermatology in Emergency Care (Feb. 12 issue),1 Dr. Greaves incorrectly uses the generic name ephedrine for a 2 percent phenylephrine spray used to treat a localized mucosal reaction. Phenylephrine hydrochloride is an {alpha}-adrenergic agonist that is useful for topical as well as intravenous vasoconstriction. It is commonly dispensed (in the United States, at least) as a 1 percent concentration. Ephedrine, a generic, indirect-acting sympathomimetic agent, is ubiquitous in perioperative care. It is dispensed in 5 percent ampules that are generally diluted before use. These drugs are therefore not equivalent.


Timothy B. Gilbert, M.D.
. . . [Full Text of this Article]

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