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Previous Volume 338:166-169 January 15, 1998 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Editorial by Van Steirteghem, A. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

High rates of successful pregnancy after in vitro fertilization depend on placing more than one embryo into the mother, a practice resulting in a 30-to-35-fold increase in dizygotic-twin deliveries.¹ Increased frequencies of twin-associated anomalies might also therefore be expected. Chimerism, the presence in a single person of cells derived from two or more zygotes, is one such rare anomaly. It is usually ascertained through anomalous blood-grouping results or (for XX/XY chimeras) sex reversal or intersex.

We used DNA polymorphisms to investigate a 46,XX/46,XY hermaphrodite conceived by in vitro fertilization. We found not only that the child is a chimera, but . . . [Full Text of this Article]

Case Report

Methods

Results

Demonstration of Chimerism by Analysis of DNA Polymorphisms

Origin of Chimerism

Discussion

Source Information

From the Human Genetics Unit, University of Edinburgh, Western General Hospital, Edinburgh (L.S., D.T.B.); the Department of Medical Genetics, Aberdeen Royal Infirmary (J.C.S.D.), and the Assisted Reproduction Unit, University Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital (M.P.R.H.), Aberdeen — all in the United Kingdom.

Address reprint requests to Dr. Bonthron at the Human Genetics Unit, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.

References

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