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Previous Volume 338:194-195 January 15, 1998 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The birth in 1978 of Louise Brown, the first child conceived by in vitro fertilization, may be considered a milestone in the alleviation of long-standing infertility for many couples, especially those with female-factor infertility. But it became clear after about 10 years of experience that conventional in vitro fertilization was unable to help couples with severe male-factor infertility. Subsequently, direct injection of a single spermatozoon into the cytoplasm of an oocyte in vitro became feasible, and the first child conceived in this way was born in 1992.¹

Intracytoplasmic sperm injection can be used successfully for men with severe oligospermia, and . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Seli, E., Sakkas, D. (2005). Spermatozoal nuclear determinants of reproductive outcome: implications for ART. Hum Reprod Update 11: 337-349 [Abstract] [Full Text]  
• Ward, M. A. (2005). Intracytoplasmic Sperm Injection Effects in Infertile azh Mutant Mice. Biol. Reprod. 73: 193-200 [Abstract] [Full Text]  
• Schwarzler, P., Zech, H., Auer, M., Pfau, K., Gobel, G., Vanderzwalmen, P., Zech, N. (2004). Pregnancy outcome after blastocyst transfer as compared to early cleavage stage embryo transfer. Hum Reprod 19: 2097-2102 [Abstract] [Full Text]  
• Hansen, M., Kurinczuk, J. J., Bower, C., Webb, S. (2002). The Risk of Major Birth Defects after Intracytoplasmic Sperm Injection and in Vitro Fertilization. NEJM 346: 725-730 [Abstract] [Full Text]  
• Dulioust, E., Busnel, M.-C., Carlier, M., Roubertoux, P., Auroux, M. (1999). Embryo cryopreservation and development: facts, questions and responsibility. Hum Reprod 14: 1141-1145 [Full Text]