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Correspondence
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Volume 338:201-202 January 15, 1998 Number 3
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Fatal Intoxication with 1,1-Dichloro-1-Fluoroethane

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To the Editor: Astier and Paraire (Sept. 25 issue)1 describe the fatal intoxication of a man in the process of cleaning a degreasing tank with 1,1-dichloro-1-fluoroethane. The available information suggests that the man died of respiratory arrest. The authors conclude that "laboratory studies are urgently needed to determine the toxicity profile of 1,1-dichloro-1-fluoroethane and propose guidelines for its safe handling."

Investigations of the physiologic effects of 1,1-dichloro-1-fluoroethane were performed in the 1940s and 1950s when this and related compounds were being tested for their usefulness as inhalational anesthetics. In 1946 Robbins2 reported that 1,1-dichloro-1-fluoroethane was an anesthetic in mice and . . . [Full Text of this Article]

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