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Previous Volume 338:321-322 January 29, 1998 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In 1891, Romberg described the autopsy findings in a patient with unexplained pulmonary hypertension.¹ For decades thereafter, case reports and small series added to this original report. About a half-century later, after the introduction of right-heart catheterization in humans, Dresdale showed that the intravenous administration of tolazoline, a systemic vasodilator, could decrease pulmonary vascular resistance in patients with unexplained pulmonary hypertension, which he designated "primary" pulmonary hypertension. Others subsequently tested a variety of systemic vasodilators for their hemodynamic effects and embarked on short trials of therapy.¹ However, until the 1990s, the only study in which drugs improved survival was a . . . [Full Text of this Article]

References

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• Herrick, A. L. (2005). Pathogenesis of Raynaud's phenomenon. Rheumatology (Oxford) 44: 587-596 [Abstract] [Full Text]  
• Gaine, S. (2000). Pulmonary Hypertension. JAMA 284: 3160-3168 [Abstract] [Full Text]  
• Hoeper, M. M., Schwarze, M., Ehlerding, S., Adler-Schuermeyer, A., Spiekerkoetter, E., Niedermeyer, J., Hamm, M., Fabel, H. (2000). Long-Term Treatment of Primary Pulmonary Hypertension with Aerosolized Iloprost, a Prostacyclin Analogue. NEJM 342: 1866-1870 [Abstract] [Full Text]  
• Berger, R.M.F. (2000). Possibilities and impossibilities in the evaluation of pulmonary vascular disease in congenital heart defects. Eur Heart J 21: 17-27