The attraction of leukocytes to tissues is essential for inflammationand the host response to infection. The process is controlledby chemokines, which are chemotactic cytokines. This reviewintroduces the burgeoning family of cytokines, with specialemphasis on their role in the pathophysiology of disease andtheir potential as targets for therapy.
Structure and Function of Chemokines
Over 40 chemokines have been identified to date, most of themin the past few years. The relations among chemokines were notinitially appreciated, which led to an idiosyncratic nomenclatureconsisting of many acronyms. When initially identified, theseproteins had no known biologic activity but were associatedwith . . . [Full Text of this Article]
Chemokine Receptors
Role in Leukocyte Movement
Role in Inflammatory Diseases
Role in Infectious Diseases
Modulation of Angiogenesis, Tumor Growth, and Stem-Cell Proliferation
Studies in Animals
Conclusions
Source Information
From the Infectious Disease Unit, Partners AIDS Research Center, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School — both in Boston.
Address reprint requests to Dr. Luster at the Infectious Disease Unit, Massachusetts General Hospital East, Bldg. 149, 13th St., Charlestown, MA 02129.
References
This article has been cited by other articles:
Antonelli, A., Ferrari, S. M., Fallahi, P., Frascerra, S., Piaggi, S., Gelmini, S., Lupi, C., Minuto, M., Berti, P., Benvenga, S., Basolo, F., Orlando, C., Miccoli, P.
(2009). Dysregulation of secretion of CXC {alpha}-chemokine CXCL10 in papillary thyroid cancer: modulation by peroxisome proliferator-activated receptor-{gamma} agonists. Endocr Relat Cancer
16: 1299-1311
[Abstract][Full Text]
Apostolakis, S., Vogiatzi, K., Amanatidou, V., Spandidos, D. A.
(2009). Interleukin 8 and cardiovascular disease. Cardiovasc Res
84: 353-360
[Abstract][Full Text]
Solinas, G., Germano, G., Mantovani, A., Allavena, P.
(2009). Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J. Leukoc. Biol.
86: 1065-1073
[Abstract][Full Text]
Vollmar, B., Menger, M. D.
(2009). The Hepatic Microcirculation: Mechanistic Contributions and Therapeutic Targets in Liver Injury and Repair. Physiol. Rev.
89: 1269-1339
[Abstract][Full Text]
Siekmann, A. F., Standley, C., Fogarty, K. E., Wolfe, S. A., Lawson, N. D.
(2009). Chemokine signaling guides regional patterning of the first embryonic artery. Genes Dev.
23: 2272-2277
[Abstract][Full Text]
Passos, G. F., Figueiredo, C. P., Prediger, R. D. S., Pandolfo, P., Duarte, F. S., Medeiros, R., Calixto, J. B.
(2009). Role of the Macrophage Inflammatory Protein-1{alpha}/CC Chemokine Receptor 5 Signaling Pathway in the Neuroinflammatory Response and Cognitive Deficits Induced by {beta}-Amyloid Peptide. Am. J. Pathol.
175: 1586-1597
[Abstract][Full Text]
Ni, J., McLoughlin, R. M., Brodovitch, A., Moulin, P., Brouckaert, P., Casadei, B., Feron, O., Topley, N., Balligand, J.-Luc., Devuyst, O.
(2009). Nitric oxide synthase isoforms play distinct roles during acute peritonitis. Nephrol Dial Transplant
0: gfp415v1-gfp415
[Abstract][Full Text]
Goyal, S., Chauhan, S. K., Zhang, Q., Dana, R.
(2009). Amelioration of Murine Dry Eye Disease by Topical Antagonist to Chemokine Receptor 2. Arch Ophthalmol
127: 882-887
[Abstract][Full Text]
Lata, S., Raghava, G.P.S.
(2009). Prediction and classification of chemokines and their receptors. Protein Eng Des Sel
22: 441-444
[Abstract][Full Text]
Altenburg, J. D., Siddiqui, R. A.
(2009). Omega-3 Polyunsaturated Fatty Acids Down-Modulate CXCR4 Expression and Function in MDA-MB-231 Breast Cancer Cells. Mol Cancer Res
7: 1013-1020
[Abstract][Full Text]
Secher, T., Vasseur, V., Poisson, D. M., Mitchell, J. A., Cunha, F. Q., Alves-Filho, J. C., Ryffel, B.
(2009). Crucial Role of TNF Receptors 1 and 2 in the Control of Polymicrobial Sepsis. J. Immunol.
182: 7855-7864
[Abstract][Full Text]
Barroso-Gonzalez, J., El Jaber-Vazdekis, N., Garcia-Exposito, L., Machado, J.-D., Zarate, R., Ravelo, A. G., Estevez-Braun, A., Valenzuela-Fernandez, A.
(2009). The Lupane-type Triterpene 30-Oxo-calenduladiol Is a CCR5 Antagonist with Anti-HIV-1 and Anti-chemotactic Activities. J. Biol. Chem.
284: 16609-16620
[Abstract][Full Text]
Couty, J.-P., Lupu-Meiri, M., Oron, Y., Gershengorn, M. C.
(2009). Kaposi's Sarcoma-Associated Herpesvirus-G Protein-Coupled Receptor-Expressing Endothelial Cells Exhibit Reduced Migration and Stimulated Chemotaxis by Chemokine Inverse Agonists. J. Pharmacol. Exp. Ther.
329: 1142-1147
[Abstract][Full Text]
Antonelli, A., Ferrari, S. M., Fallahi, P., Frascerra, S., Santini, E., Franceschini, S. S., Ferrannini, E.
(2009). Monokine Induced by Interferon {gamma} (IFN{gamma}) (CXCL9) and IFN{gamma} Inducible T-Cell {alpha}-Chemoattractant (CXCL11) Involvement in Graves' Disease and Ophthalmopathy: Modulation by Peroxisome Proliferator-Activated Receptor-{gamma} Agonists. J. Clin. Endocrinol. Metab.
94: 1803-1809
[Abstract][Full Text]
Raz, E., Mahabaleshwar, H.
(2009). Chemokine signaling in embryonic cell migration: a fisheye view. Development
136: 1223-1229
[Abstract][Full Text]
Crawford, M. A., Zhu, Y., Green, C. S., Burdick, M. D., Sanz, P., Alem, F., O'Brien, A. D., Mehrad, B., Strieter, R. M., Hughes, M. A.
(2009). Antimicrobial Effects of Interferon-Inducible CXC Chemokines against Bacillus anthracis Spores and Bacilli. Infect. Immun.
77: 1664-1678
[Abstract][Full Text]
Russo, R. C., Guabiraba, R., Garcia, C. C., Barcelos, L. S., Roffe, E., Souza, A. L. S., Amaral, F. A., Cisalpino, D., Cassali, G. D., Doni, A., Bertini, R., Teixeira, M. M.
(2009). Role of the Chemokine Receptor CXCR2 in Bleomycin-Induced Pulmonary Inflammation and Fibrosis. Am. J. Respir. Cell Mol. Bio.
40: 410-421
[Abstract][Full Text]
El Kebir, D., Jozsef, L., Pan, W., Wang, L., Filep, J. G.
(2009). Bacterial DNA Activates Endothelial Cells and Promotes Neutrophil Adherence through TLR9 Signaling. J. Immunol.
182: 4386-4394
[Abstract][Full Text]
Joly, S., Samardzija, M., Wenzel, A., Thiersch, M., Grimm, C.
(2009). Nonessential Role of {beta}3 and {beta}5 Integrin Subunits for Efficient Clearance of Cellular Debris after Light-Induced Photoreceptor Degeneration. IOVS
50: 1423-1432
[Abstract][Full Text]
Xing, D., Nozell, S., Chen, Y.-F., Hage, F., Oparil, S.
(2009). Estrogen and Mechanisms of Vascular Protection. Arterioscler. Thromb. Vasc. Bio.
29: 289-295
[Abstract][Full Text]
Shaik, S. S., Soltau, T. D., Chaturvedi, G., Totapally, B., Hagood, J. S., Andrews, W. W., Athar, M., Voitenok, N. N., Killingsworth, C. R., Patel, R. P., Fallon, M. B., Maheshwari, A.
(2009). Low Intensity Shear Stress Increases Endothelial ELR+ CXC Chemokine Production via a Focal Adhesion Kinase-p38{beta} MAPK-NF-{kappa}B Pathway. J. Biol. Chem.
284: 5945-5955
[Abstract][Full Text]
Stevenson, N. J., Addley, M. R., Ryan, E. J., Boyd, C. R., Carroll, H. P., Paunovic, V., Bursill, C. A., Miller, H. C., Channon, K. M., McClurg, A. E., Armstrong, M. A., Coulter, W. A., Greaves, D. R., Johnston, J. A.
(2009). CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression. J. Leukoc. Biol.
85: 289-297
[Abstract][Full Text]
Grabner, R., Lotzer, K., Dopping, S., Hildner, M., Radke, D., Beer, M., Spanbroek, R., Lippert, B., Reardon, C. A., Getz, G. S., Fu, Y.-X., Hehlgans, T., Mebius, R. E., van der Wall, M., Kruspe, D., Englert, C., Lovas, A., Hu, D., Randolph, G. J., Weih, F., Habenicht, A. J.R.
(2009). Lymphotoxin {beta} receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice. JEM
206: 233-248
[Abstract][Full Text]
He, S., Cao, Q., Qiu, Y., Mi, J., Zhang, J. Z., Jin, M., Ge, H., Emerson, S. G., Zhang, Y., Zhang, Y.
(2008). A New Approach to the Blocking of Alloreactive T Cell-Mediated Graft-versus-Host Disease by In Vivo Administration of Anti-CXCR3 Neutralizing Antibody. J. Immunol.
181: 7581-7592
[Abstract][Full Text]
Zhou, W.-H., Du, M.-R., Dong, L., Yu, J., Li, D.-J.
(2008). Chemokine CXCL12 promotes the cross-talk between trophoblasts and decidual stromal cells in human first-trimester pregnancy. Hum Reprod
23: 2669-2679
[Abstract][Full Text]
Hartl, D., He, C. H., Koller, B., Da Silva, C. A., Homer, R., Lee, C. G., Elias, J. A.
(2008). Acidic Mammalian Chitinase Is Secreted via an ADAM17/Epidermal Growth Factor Receptor-dependent Pathway and Stimulates Chemokine Production by Pulmonary Epithelial Cells. J. Biol. Chem.
283: 33472-33482
[Abstract][Full Text]
Keeley, E. C., Mehrad, B., Strieter, R. M.
(2008). Chemokines as Mediators of Neovascularization. Arterioscler. Thromb. Vasc. Bio.
28: 1928-1936
[Abstract][Full Text]
Gemelli, C., Orlandi, C., Marani, T. Z., Martello, A., Vignudelli, T., Ferrari, F., Montanari, M., Parenti, S., Testa, A., Grande, A., Ferrari, S.
(2008). The Vitamin D3/Hox-A10 Pathway Supports MafB Function during the Monocyte Differentiation of Human CD34+ Hemopoietic Progenitors. J. Immunol.
181: 5660-5672
[Abstract][Full Text]
Dean, R. A., Cox, J. H., Bellac, C. L., Doucet, A., Starr, A. E., Overall, C. M.
(2008). Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. Blood
112: 3455-3464
[Abstract][Full Text]
Hartmann, T. N., Grabovsky, V., Pasvolsky, R., Shulman, Z., Buss, E. C., Spiegel, A., Nagler, A., Lapidot, T., Thelen, M., Alon, R.
(2008). A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells. J. Leukoc. Biol.
84: 1130-1140
[Abstract][Full Text]
Handel, T. M., Johnson, Z., Rodrigues, D. H., dos Santos, A. C., Cirillo, R., Muzio, V., Riva, S., Mack, M., Deruaz, M., Borlat, F., Vitte, P.-A., Wells, T. N. C., Teixeira, M. M., Proudfoot, A. E. I.
(2008). An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo. J. Leukoc. Biol.
84: 1101-1108
[Abstract][Full Text]
Hong, S.-B., Huang, Y., Moreno-Vinasco, L., Sammani, S., Moitra, J., Barnard, J. W., Ma, S.-F., Mirzapoiazova, T., Evenoski, C., Reeves, R. R., Chiang, E. T., Lang, G. D., Husain, A. N., Dudek, S. M., Jacobson, J. R., Ye, S. Q., Lussier, Y. A., Garcia, J. G. N.
(2008). Essential Role of Pre-B-Cell Colony Enhancing Factor in Ventilator-induced Lung Injury. Am. J. Respir. Crit. Care Med.
178: 605-617
[Abstract][Full Text]
Ramachandran, A., Jha, S., Lefer, D. J.
(2008). REVIEW Paper: Pathophysiology of Myocardial Reperfusion Injury: The Role of Genetically Engineered Mouse Models. Vet Pathol
45: 698-706
[Abstract][Full Text]
Belperio, J. A, Ardehali, A.
(2008). Chemokines and Transplant Vasculopathy. Circ. Res.
103: 454-466
[Abstract][Full Text]
Barbieri, F., Bajetto, A., Stumm, R., Pattarozzi, A., Porcile, C., Zona, G., Dorcaratto, A., Ravetti, J.-L., Minuto, F., Spaziante, R., Schettini, G., Ferone, D., Florio, T.
(2008). Overexpression of Stromal Cell-Derived Factor 1 and Its Receptor CXCR4 Induces Autocrine/Paracrine Cell Proliferation in Human Pituitary Adenomas. Clin. Cancer Res.
14: 5022-5032
[Abstract][Full Text]
Forssmann, U., Stoetzer, C., Stephan, M., Kruschinski, C., Skripuletz, T., Schade, J., Schmiedl, A., Pabst, R., Wagner, L., Hoffmann, T., Kehlen, A., Escher, S. E., Forssmann, W.-G., Elsner, J., von Horsten, S.
(2008). Inhibition of CD26/Dipeptidyl Peptidase IV Enhances CCL11/Eotaxin-Mediated Recruitment of Eosinophils In Vivo. J. Immunol.
181: 1120-1127
[Abstract][Full Text]
Mares, C. A., Ojeda, S. S., Morris, E. G., Li, Q., Teale, J. M.
(2008). Initial Delay in the Immune Response to Francisella tularensis Is Followed by Hypercytokinemia Characteristic of Severe Sepsis and Correlating with Upregulation and Release of Damage-Associated Molecular Patterns. Infect. Immun.
76: 3001-3010
[Abstract][Full Text]
Kintscher, U., Hartge, M., Hess, K., Foryst-Ludwig, A., Clemenz, M., Wabitsch, M., Fischer-Posovszky, P., Barth, T. F.E., Dragun, D., Skurk, T., Hauner, H., Bluher, M., Unger, T., Wolf, A.-M., Knippschild, U., Hombach, V., Marx, N.
(2008). T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance. Arterioscler. Thromb. Vasc. Bio.
28: 1304-1310
[Abstract][Full Text]
Ngo, H. T., Leleu, X., Lee, J., Jia, X., Melhem, M., Runnels, J., Moreau, A.-S., Burwick, N., Azab, A. K., Roccaro, A., Azab, F., Sacco, A., Farag, M., Sackstein, R., Ghobrial, I. M.
(2008). SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia. Blood
112: 150-158
[Abstract][Full Text]
Murooka, T. T., Rahbar, R., Platanias, L. C., Fish, E. N.
(2008). CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1. Blood
111: 4892-4901
[Abstract][Full Text]
Hubal, M. J., Chen, T. C., Thompson, P. D., Clarkson, P. M.
(2008). Inflammatory gene changes associated with the repeated-bout effect. Am. J. Physiol. Regul. Integr. Comp. Physiol.
294: R1628-R1637
[Abstract][Full Text]
Suzaki, Y., Hamada, K., Nomi, T., Ito, T., Sho, M., Kai, Y., Nakajima, Y., Kimura, H.
(2008). A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation. Eur Respir J
31: 783-789
[Abstract][Full Text]
Antao-Menezes, A., Turpin, E. A., Bost, P. C., Ryman-Rasmussen, J. P., Bonner, J. C.
(2008). STAT-1 Signaling in Human Lung Fibroblasts Is Induced by Vanadium Pentoxide through an IFN-{beta} Autocrine Loop. J. Immunol.
180: 4200-4207
[Abstract][Full Text]
Antonelli, A., Ferri, C., Fallahi, P., Ferrari, S. M., Giuggioli, D., Colaci, M., Manfredi, A., Frascerra, S., Franzoni, F., Galetta, F., Ferrannini, E.
(2008). CXCL10 ({alpha}) and CCL2 ( ) chemokines in systemic sclerosis a longitudinal study. Rheumatology (Oxford)
47: 45-49
[Abstract][Full Text]
Alexander-Brett, J. M., Fremont, D. H.
(2007). Dual GPCR and GAG mimicry by the M3 chemokine decoy receptor. JEM
204: 3157-3172
[Abstract][Full Text]
Bieche, I., Chavey, C., Andrieu, C., Busson, M., Vacher, S., Le Corre, L., Guinebretiere, J.-M., Burlinchon, S., Lidereau, R., Lazennec, G.
(2007). CXC chemokines located in the 4q21 region are up-regulated in breast cancer. Endocr Relat Cancer
14: 1039-1052
[Abstract][Full Text]
Adachi, T., Nakanishi, T., Yumoto, H., Hirao, K., Takahashi, K., Mukai, K., Nakae, H., Matsuo, T.
(2007). Caries-related Bacteria and Cytokines Induce CXCL10 in Dental Pulp. JDR
86: 1217-1222
[Abstract][Full Text]
Takai, Y., Kitano, K., Terawaki, S.-i., Maesaki, R., Hakoshima, T.
(2007). Structural basis of PSGL-1 binding to ERM proteins.. GENES CELLS
12: 1329-1338
[Abstract][Full Text]
Sanchez, O., Marcos, E., Perros, F., Fadel, E., Tu, L., Humbert, M., Dartevelle, P., Simonneau, G., Adnot, S., Eddahibi, S.
(2007). Role of Endothelium-derived CC Chemokine Ligand 2 in Idiopathic Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med.
176: 1041-1047
[Abstract][Full Text]
Ardigo, D., Assimes, T. L., Fortmann, S. P., Go, A. S., Hlatky, M., Hytopoulos, E., Iribarren, C., Tsao, P. S., Tabibiazar, R., Quertermous, T., for the ADVANCE Investigators,
(2007). Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease. Physiol. Genomics
31: 402-409
[Abstract][Full Text]
Ribaux, P., Ehses, J. A., Lin-Marq, N., Carrozzino, F., Boni-Schnetzler, M., Hammar, E., Irminger, J.-C., Donath, M. Y., Halban, P. A.
(2007). Induction of CXCL1 by Extracellular Matrix and Autocrine Enhancement by Interleukin-1 in Rat Pancreatic {beta}-Cells. Endocrinology
148: 5582-5590
[Abstract][Full Text]
Gruen, M. L., Hao, M., Piston, D. W., Hasty, A. H.
(2007). Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis. Am. J. Physiol. Cell Physiol.
293: C1481-C1488
[Abstract][Full Text]
Plantier, L., Marchand-Adam, S., Antico, V. G., Boyer, L., De Coster, C., Marchal, J., Bachoual, R., Mailleux, A., Boczkowski, J., Crestani, B.
(2007). Keratinocyte growth factor protects against elastase-induced pulmonary emphysema in mice. Am. J. Physiol. Lung Cell. Mol. Physiol.
293: L1230-L1239
[Abstract][Full Text]
Choi, S. W., Hildebrandt, G. C., Olkiewicz, K. M., Hanauer, D. A., Chaudhary, M. N., Silva, I. A., Rogers, C. E., Deurloo, D. T., Fisher, J. M., Liu, C., Adams, D., Chensue, S. W., Cooke, K. R.
(2007). CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation. Blood
110: 3447-3455
[Abstract][Full Text]
Wu, Y.-Y., Tsai, H.-F., Lin, W.-C., Hsu, P.-I, Shun, C.-T., Wu, M.-S., Hsu, P.-N.
(2007). Upregulation of CCL20 and Recruitment of CCR6+ Gastric Infiltrating Lymphocytes in Helicobacter pylori Gastritis. Infect. Immun.
75: 4357-4363
[Abstract][Full Text]
Thalmann, S., Meier, C. A.
(2007). Local adipose tissue depots as cardiovascular risk factors. Cardiovasc Res
75: 690-701
[Abstract][Full Text]
Schroder, C., Pierson, R. N. III, Nguyen, B.-N. H., Kawka, D. W., Peterson, L. B., Wu, G., Zhang, T., Springer, M. S., Siciliano, S. J., Iliff, S., Ayala, J. M., Lu, M., Mudgett, J. S., Lyons, K., Mills, S. G., Miller, G. G., Singer, I. I., Azimzadeh, A. M., DeMartino, J. A.
(2007). CCR5 Blockade Modulates Inflammation and Alloimmunity in Primates. J. Immunol.
179: 2289-2299
[Abstract][Full Text]
Tanabe, S.-i., Bodet, C., Grenier, D.
(2007). Peptostreptococcus micros cell wall elicits a pro-inflammatory response in human macrophages. Innate Immunity
13: 219-226
[Abstract]
Glasgow, S. C., Ramachandran, S., Blackwell, T. S., Mohanakumar, T., Chapman, W. C.
(2007). Interleukin-1beta is the primary initiator of pulmonary inflammation following liver injury in mice. Am. J. Physiol. Lung Cell. Mol. Physiol.
293: L491-L496
[Abstract][Full Text]
Yuan, Q., Bromley, S. K., Means, T. K., Jones, K. J., Hayashi, F., Bhan, A. K., Luster, A. D.
(2007). CCR4-dependent regulatory T cell function in inflammatory bowel disease. JEM
204: 1327-1334
[Abstract][Full Text]
Inukai, Y., Momobayashi, A., Sugawara, N., Aso, Y.
(2007). Changes in expression of T-helper (Th) 1- and Th2-associated chemokine receptors on peripheral blood lymphocytes and plasma concentrations of their ligands, interferon-inducible protein-10 and thymus and activation-regulated chemokine, after antithyroid drug administration in hyperthyroid patients with Graves' disease. Eur J Endocrinol
156: 623-630
[Abstract][Full Text]
Stienstra, R., Mandard, S., Patsouris, D., Maass, C., Kersten, S., Muller, M.
(2007). Peroxisome Proliferator-Activated Receptor {alpha} Protects against Obesity-Induced Hepatic Inflammation. Endocrinology
148: 2753-2763
[Abstract][Full Text]
Xing, D., Feng, W., Miller, A. P., Weathington, N. M., Chen, Y.-F., Novak, L., Blalock, J. E., Oparil, S.
(2007). Estrogen modulates TNF-{alpha}-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation. Am. J. Physiol. Heart Circ. Physiol.
292: H2607-H2612
[Abstract][Full Text]
Shanbhag, A. S., Kaufman, A. M., Hayata, K., Rubash, H. E.
(2007). Assessing Osteolysis with Use of High-Throughput Protein Chips. JBJS
89: 1081-1089
[Abstract][Full Text]
de Jager, W., Hoppenreijs, E. P A H, Wulffraat, N. M, Wedderburn, L. R, Kuis, W., Prakken, B. J
(2007). Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study. Ann Rheum Dis
66: 589-598
[Abstract][Full Text]
Mitchell, R. N., Libby, P.
(2007). Vascular Remodeling in Transplant Vasculopathy. Circ. Res.
100: 967-978
[Abstract][Full Text]
Nomura, S., Ishii, K., Kamitsuji, Y., Uoshima, N., Ishikawa, E., Kitayama, H., Hayashi, K.
(2007). Elevation of Activated Platelet-Dependent Chemokines in Patients With Anti-CD20 Monoclonal Antibody (Rituximab)-Treated Non-Hodgkin's Lymphoma. CLIN APPL THROMB HEMOST
13: 206-212
[Abstract]
Cavusoglu, E., Eng, C., Chopra, V., Clark, L. T., Pinsky, D. J., Marmur, J. D.
(2007). Low Plasma RANTES Levels Are an Independent Predictor of Cardiac Mortality in Patients Referred for Coronary Angiography. Arterioscler. Thromb. Vasc. Bio.
27: 929-935
[Abstract][Full Text]
Ninichuk, V., Khandoga, A. G., Segerer, S., Loetscher, P., Schlapbach, A., Revesz, L., Feifel, R., Khandoga, A., Krombach, F., Nelson, P. J., Schlondorff, D., Anders, H.-J.
(2007). The Role of Interstitial Macrophages in Nephropathy of Type 2 Diabetic db/db Mice. Am. J. Pathol.
170: 1267-1276
[Abstract][Full Text]
He, M., Horuk, R., Moochhala, S. M., Bhatia, M.
(2007). Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis. Am. J. Physiol. Gastrointest. Liver Physiol.
292: G1173-G1180
[Abstract][Full Text]
Alsayed, Y., Ngo, H., Runnels, J., Leleu, X., Singha, U. K., Pitsillides, C. M., Spencer, J. A., Kimlinger, T., Ghobrial, J. M., Jia, X., Lu, G., Timm, M., Kumar, A., Cote, D., Veilleux, I., Hedin, K. E., Roodman, G. D., Witzig, T. E., Kung, A. L., Hideshima, T., Anderson, K. C., Lin, C. P., Ghobrial, I. M.
(2007). Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma. Blood
109: 2708-2717
[Abstract][Full Text]
Guyon, A., Nahon, J.-L.
(2007). Multiple actions of the chemokine stromal cell-derived factor-1{alpha} on neuronal activity. J Mol Endocrinol
38: 365-376
[Abstract][Full Text]
Barbieri, F., Bajetto, A., Porcile, C., Pattarozzi, A., Schettini, G., Florio, T.
(2007). Role of stromal cell-derived factor 1 (SDF1/CXCL12) in regulating anterior pituitary function. J Mol Endocrinol
38: 383-389
[Abstract][Full Text]
Ebihara, N., Yamagami, S., Yokoo, S., Amano, S., Murakami, A.
(2007). Involvement of C-C Chemokine Ligand 2-CCR2 Interaction in Monocyte-Lineage Cell Recruitment of Normal Human Corneal Stroma. J. Immunol.
178: 3288-3292
[Abstract][Full Text]
Melar, M., Ott, D. E., Hope, T. J.
(2007). Physiological Levels of Virion-Associated Human Immunodeficiency Virus Type 1 Envelope Induce Coreceptor-Dependent Calcium Flux. J. Virol.
81: 1773-1785
[Abstract][Full Text]
Martinez de la Torre, Y., Buracchi, C., Borroni, E. M., Dupor, J., Bonecchi, R., Nebuloni, M., Pasqualini, F., Doni, A., Lauri, E., Agostinis, C., Bulla, R., Cook, D. N., Haribabu, B., Meroni, P., Rukavina, D., Vago, L., Tedesco, F., Vecchi, A., Lira, S. A., Locati, M., Mantovani, A.
(2007). Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6. Proc. Natl. Acad. Sci. USA
104: 2319-2324
[Abstract][Full Text]
Dobrzanski, M. J., Reome, J. B., Hylind, J. C., Rewers-Felkins, K. A.
(2006). CD8-Mediated Type 1 Antitumor Responses Selectively Modulate Endogenous Differentiated and Nondifferentiated T Cell Localization, Activation, and Function in Progressive Breast Cancer. J. Immunol.
177: 8191-8201
[Abstract][Full Text]
Lee, S.-J., Namkoong, S., Kim, Y.-M., Kim, C.-K., Lee, H., Ha, K.-S., Chung, H.-T., Kwon, Y.-G., Kim, Y.-M.
(2006). Fractalkine stimulates angiogenesis by activating the Raf-1/MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways. Am. J. Physiol. Heart Circ. Physiol.
291: H2836-H2846
[Abstract][Full Text]
Riccioli, A., Starace, D., Galli, R., Fuso, A., Scarpa, S., Palombi, F., De Cesaris, P., Ziparo, E., Filippini, A.
(2006). Sertoli Cells Initiate Testicular Innate Immune Responses through TLR Activation. J. Immunol.
177: 7122-7130
[Abstract][Full Text]
Shanmugam, N., Ransohoff, R. M., Natarajan, R.
(2006). Interferon-{gamma}-inducible Protein (IP)-10 mRNA Stabilized by RNA-binding Proteins in Monocytes Treated with S100b. J. Biol. Chem.
281: 31212-31221
[Abstract][Full Text]
Shahrara, S., Park, C. C., Temkin, V., Jarvis, J. W., Volin, M. V., Pope, R. M.
(2006). RANTES Modulates TLR4-Induced Cytokine Secretion in Human Peripheral Blood Monocytes. J. Immunol.
177: 5077-5087
[Abstract][Full Text]
Antoniou, K. M., Tzouvelekis, A., Alexandrakis, M. G., Sfiridaki, K., Tsiligianni, I., Rachiotis, G., Tzanakis, N., Bouros, D., Milic-Emili, J., Siafakas, N. M.
(2006). Different angiogenic activity in pulmonary sarcoidosis and idiopathic pulmonary fibrosis.. Chest
130: 982-988
[Abstract][Full Text]
Long, K. Z., Santos, J. I., Estrada Garcia, T., Haas, M., Firestone, M., Bhagwat, J., DuPont, H. L., Hertzmark, E., Rosado, J. L., Nanthakumar, N. N.
(2006). Vitamin A Supplementation Reduces the Monocyte Chemoattractant Protein-1 Intestinal Immune Response of Mexican Children. J. Nutr.
136: 2600-2605
[Abstract][Full Text]
Puellmann, K., Kaminski, W. E., Vogel, M., Nebe, C. T., Schroeder, J., Wolf, H., Beham, A. W.
(2006). From the Cover: A variable immunoreceptor in a subpopulation of human neutrophils. Proc. Natl. Acad. Sci. USA
103: 14441-14446
[Abstract][Full Text]
Takase, H., Yu, C.-R., Ham, D.-I., Chan, C.-C., Chen, J., Vistica, B. P., Wawrousek, E. F., Durum, S. K., Egwuagu, C. E., Gery, I.
(2006). Inflammatory processes triggered by TCR engagement or by local cytokine expression: differences in profiles of gene expression and infiltrating cell populations. J. Leukoc. Biol.
80: 538-545
[Abstract][Full Text]
Chen, J.-P., Lu, H.-L., Lai, S.-L., Campanella, G. S., Sung, J.-M., Lu, M.-Y., Wu-Hsieh, B. A., Lin, Y.-L., Lane, T. E., Luster, A. D., Liao, F.
(2006). Dengue Virus Induces Expression of CXC Chemokine Ligand 10/IFN-{gamma}-Inducible Protein 10, Which Competitively Inhibits Viral Binding to Cell Surface Heparan Sulfate.. J. Immunol.
177: 3185-3192
[Abstract][Full Text]
Murooka, T. T., Wong, M. M., Rahbar, R., Majchrzak-Kita, B., Proudfoot, A. E. I., Fish, E. N.
(2006). CCL5-CCR5-mediated Apoptosis in T Cells: REQUIREMENT FOR GLYCOSAMINOGLYCAN BINDING AND CCL5 AGGREGATION. J. Biol. Chem.
281: 25184-25194
[Abstract][Full Text]
Suttmann, H., Riemensberger, J., Bentien, G., Schmaltz, D., Stockle, M., Jocham, D., Bohle, A., Brandau, S.
(2006). Neutrophil Granulocytes Are Required for Effective Bacillus Calmette-Guerin Immunotherapy of Bladder Cancer and Orchestrate Local Immune Responses. Cancer Res.
66: 8250-8257
[Abstract][Full Text]
Colvin, R. A., Campanella, G. S. V., Manice, L. A., Luster, A. D.
(2006). CXCR3 Requires Tyrosine Sulfation for Ligand Binding and a Second Extracellular Loop Arginine Residue for Ligand-Induced Chemotaxis. Mol. Cell. Biol.
26: 5838-5849
[Abstract][Full Text]
Kawauchi, Y., Suzuki, K., Watanabe, S., Yamagiwa, S., Yoneyama, H., Han, G. D., Palaniyandi, S. S., Veeraveedu, P. T., Watanabe, K., Kawachi, H., Okada, Y., Shimizu, F., Asakura, H., Aoyagi, Y., Narumi, S.
(2006). Role of IP-10/CXCL10 in the progression of pancreatitis-like injury in mice after murine retroviral infection.. Am. J. Physiol. Gastrointest. Liver Physiol.
291: G345-G354
[Abstract][Full Text]
Sironi, M., Martinez, F. O., D'Ambrosio, D., Gattorno, M., Polentarutti, N., Locati, M., Gregorio, A., Iellem, A., Cassatella, M. A., Van Damme, J., Sozzani, S., Martini, A., Sinigaglia, F., Vecchi, A., Mantovani, A.
(2006). Differential regulation of chemokine production by Fc{gamma} receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2). J. Leukoc. Biol.
80: 342-349
[Abstract][Full Text]
Potteaux, S., Combadiere, C., Esposito, B., Lecureuil, C., Ait-Oufella, H., Merval, R., Ardouin, P., Tedgui, A., Mallat, Z.
(2006). Role of Bone Marrow-Derived CC-Chemokine Receptor 5 in the Development of Atherosclerosis of Low-Density Lipoprotein Receptor Knockout Mice. Arterioscler. Thromb. Vasc. Bio.
26: 1858-1863
[Abstract][Full Text]
Adess, M., Eisner, R., Nand, S., Godwin, J., Messmore, H. L. Jr, Wehrmacher, W. H.
(2006). Thromboembolism in Cancer Patients: Pathogenesis and Treatment. CLIN APPL THROMB HEMOST
12: 254-266
[Abstract]
Previous
