The attraction of leukocytes to tissues is essential for inflammationand the host response to infection. The process is controlledby chemokines, which are chemotactic cytokines. This reviewintroduces the burgeoning family of cytokines, with specialemphasis on their role in the pathophysiology of disease andtheir potential as targets for therapy.
Structure and Function of Chemokines
Over 40 chemokines have been identified to date, most of themin the past few years. The relations among chemokines were notinitially appreciated, which led to an idiosyncratic nomenclatureconsisting of many acronyms. When initially identified, theseproteins had no known biologic activity but were associatedwith . . . [Full Text of this Article]
Chemokine Receptors
Role in Leukocyte Movement
Role in Inflammatory Diseases
Role in Infectious Diseases
Modulation of Angiogenesis, Tumor Growth, and Stem-Cell Proliferation
Studies in Animals
Conclusions
Source Information
From the Infectious Disease Unit, Partners AIDS Research Center, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School — both in Boston.
Address reprint requests to Dr. Luster at the Infectious Disease Unit, Massachusetts General Hospital East, Bldg. 149, 13th St., Charlestown, MA 02129.
References
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