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Review Article
Mechanisms of Disease
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Volume 338:436-445 February 12, 1998 Number 7
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Chemokines — Chemotactic Cytokines That Mediate Inflammation
Andrew D. Luster, M.D., Ph.D.

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The attraction of leukocytes to tissues is essential for inflammation and the host response to infection. The process is controlled by chemokines, which are chemotactic cytokines. This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy.

Structure and Function of Chemokines

Over 40 chemokines have been identified to date, most of them in the past few years. The relations among chemokines were not initially appreciated, which led to an idiosyncratic nomenclature consisting of many acronyms. When initially identified, these proteins had no known biologic activity but were associated with . . . [Full Text of this Article]

Chemokine Receptors

Role in Leukocyte Movement

Role in Inflammatory Diseases

Role in Infectious Diseases

Modulation of Angiogenesis, Tumor Growth, and Stem-Cell Proliferation

Studies in Animals

Conclusions


Source Information

From the Infectious Disease Unit, Partners AIDS Research Center, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School — both in Boston.

Address reprint requests to Dr. Luster at the Infectious Disease Unit, Massachusetts General Hospital East, Bldg. 149, 13th St., Charlestown, MA 02129.

References


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