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Previous Volume 338:548 February 19, 1998 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Kupfer and Tessler (Oct. 23 issue)¹ report a possible association of ticlopidine with fatal thrombotic thrombocytopenic purpura in two patients, but they imply that platelet transfusion is standard therapy for thrombotic thrombocytopenic purpura. In fact, the report illustrates the potential hazard of platelet transfusion for the condition. Platelet transfusions have been temporally associated with severe exacerbations of thrombotic thrombocytopenic purpura,^2,3 including rapid deterioration and death, as occurred in one of the women described by Kupfer and Tessler, who died within six hours after platelet transfusion. The most likely mechanism for the adverse effect appears to be exacerbation . . . [Full Text of this Article]

References

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