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Previous Volume 339:27-31 July 2, 1998 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Cortisol-secreting adrenal adenomas are an uncommon cause of Cushing's syndrome. Little is known about the events leading to the formation of these tumors, but molecular defects, including activating mutations of receptors for corticotropic factors, have been suspected in this process. Structural mutations of the corticotropin-receptor gene have not been detected in these tumors,¹ but some have had gastric inhibitory polypeptide,^2,3 vasopressin,⁴ and more recently, -adrenergic receptors.⁵

In this report, we provide evidence of the involvement of immune cells and one of their cytokine products in the formation of an adrenocortical adenoma in a patient with Cushing's syndrome. A striking lymphocytic . . . [Full Text of this Article]

Case Report

Methods

Tissue Processing

Immunohistochemical Analysis

In Situ Hybridization

Isolation of RNA and Reverse-Transcription PCR

Extraction of DNA and Analysis of Clonality

Cell-Culture Experiments

Results

Histologic Examination

Immunohistochemical Analysis

In Situ Hybridization

Reverse-Transcription PCR

Hormonal Measurements

Discussion

Source Information

From the Department of Internal Medicine III, University of Leipzig, Leipzig, Germany (H.S.W., C.M.); and the National Institute of Child Health and Human Development (H.S.W., C.A.S., G.P.C., S.R.B.) and the National Institute of Mental Health (M.E.-B.), National Institutes of Health Clinical Center, Bethesda, Md.

Address reprint requests to Dr. Bornstein at the National Institutes of Health, NIH Clinical Center, NICHD, Bldg. 10, Rm. 10N262, Bethesda, MD 20892.

References

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