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Correspondence
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Volume 339:705 September 3, 1998 Number 10
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Hepatitis A Vaccination

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To the Editor: Werzberger et al. (April 16 issue)1 report that on the basis of six years of follow-up after the Monroe efficacy trial, vaccination against hepatitis A is protective. However, it still remains to be determined how long the vaccine will be effective. We know that the level of antibody after immunization with either one of the commercially available vaccines is much lower than the level associated with natural infection. Standard assays with a lower limit of detection of 100 mIU per milliliter usually fail to detect vaccine-induced levels of hepatitis A virus antibody. Once there has been exposure . . . [Full Text of this Article]

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