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Correspondence
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Volume 339:773-774 September 10, 1998 Number 11
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HIV-Protease Inhibitors

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 by Flexner, C.
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To the Editor: In his review of inhibitors of human immunodeficiency virus (HIV)–encoded protease (April 30 issue),1 Dr. Flexner states that ritonavir causes hypertriglyceridemia in no more than 5 percent of patients and has not caused pancreatitis. However, we found that of 52 patients treated with ritonavir for six months, 41 (79 percent) had hypertriglyceridemia (serum triglyceride concentration, >160 mg per deciliter [1.8 mmol per liter]), with values higher than 500 mg per deciliter (5.6 mmol per liter) in 22 patients (42 percent) and higher than 1000 mg per deciliter (11.3 mmol per liter) in 8 (15 percent). The risk . . . [Full Text of this Article]

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