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That screening mammography substantially reduces mortality from breast cancer is a major medical accomplishment of our time and one with potential remaining to be fulfilled. During its development, mammography has taught us much about the biology of breast cancer, the validation and quantification of both the benefit and the potential harm of screening, the relation of technical and interpretive quality to outcomes, the need for scientific assessment of new imaging methods that might supplement or replace mammography, and the uncertainties of mammographic interpretation. In each of these areas, the history of mammography provides invaluable lessons that are applicable to the
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