Doxorubicin (Adriamycin) has been used in oncologic practicesince the late 1960s. It held promise as a powerful drug inthe fight against cancer. The tumors most commonly respondingto doxorubicin when it is given as a single agent or in combinationwith other antitumor agents include breast and esophageal carcinomas;osteosarcoma, Kaposi's sarcoma, and soft-tissue sarcomas; andHodgkin's and non-Hodgkin's lymphomas. Other cancers that areless responsive to doxorubicin but that are still treated withthe drug because of its overall benefits include gastric, liver,bile-duct, pancreatic, and endometrial carcinomas. However,reports of fatal cardiotoxic effects of doxorubicin have . . . [Full Text of this Article]
Cause
Diagnosis
Physical Examination
Electrocardiography
Echocardiography and Angiocardiography
Endomyocardial Biopsy
Management
Prevention
Use of Analogues and "Cocktails"
Alternative Approaches to Drug Delivery
Cardioprotective Agents
Treatment
Future Prospects
Conclusions
Source Information
From the Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, and the Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Man., Canada.
Address reprint requests to Dr. Singal at the Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, 351 Tache Ave., Rm. R3022, Winnipeg, MB R2H 2A6, Canada.
References
Related Letters:
Doxorubicin-Induced Cardiomyopathy
Lipshultz S. E., Grenier M. A., Colan S. D., Ginsburg A. D., Swain S. M., Muggia F. M., Speyer J. L., Singal P. K., Olweny C. L.M., Li T.
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N Engl J Med 1999;
340:653-655, Feb 25, 1999.
Correspondence
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Christiansen, S., Autschbach, R.
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30: 611-616
[Abstract][Full Text]
Neilan, T. G., Jassal, D. S., Perez-Sanz, T. M., Raher, M. J., Pradhan, A. D., Buys, E. S., Ichinose, F., Bayne, D. B., Halpern, E. F., Weyman, A. E., Derumeaux, G., Bloch, K. D., Picard, M. H., Scherrer-Crosbie, M.
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[Abstract][Full Text]
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[Abstract][Full Text]
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(2006). Long-term cardiac toxicity after adjuvant epirubicin-based chemotherapy in early breast cancer: French Adjuvant Study Group Results. Ann Oncol
17: 85-92
[Abstract][Full Text]
Doyle, J. J., Neugut, A. I., Jacobson, J. S., Grann, V. R., Hershman, D. L.
(2005). Chemotherapy and Cardiotoxicity in Older Breast Cancer Patients: A Population-Based Study. JCO
23: 8597-8605
[Abstract][Full Text]
Del Mastro, L., Perrone, F.
(2005). Reply to "Weekly paclitaxel in elderly breast cancer patients", by C. Smorenburg et al. (Ann Oncol 2005; 16: 1979). Ann Oncol
16: 1979-1980
[Full Text]
Ewer, M. S., Vooletich, M. T., Durand, J.-B., Woods, M. L., Davis, J. R., Valero, V., Lenihan, D. J.
(2005). Reversibility of Trastuzumab-Related Cardiotoxicity: New Insights Based on Clinical Course and Response to Medical Treatment. JCO
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[Abstract][Full Text]
Iwasaki, M., Adachi, Y., Nishiue, T., Minamino, K., Suzuki, Y., Zhang, Y., Nakano, K., Koike, Y., Wang, J., Mukaide, H., Taketani, S., Yuasa, F., Tsubouchi, H., Gohda, E., Iwasaka, T., Ikehara, S.
(2005). Hepatocyte Growth Factor Delivered by Ultrasound-Mediated Destruction of Microbubbles Induces Proliferation of Cardiomyocytes and Amelioration of Left Ventricular Contractile Function in Doxorubicin-Induced Cardiomyopathy. Stem Cells
23: 1589-1597
[Abstract][Full Text]
Simsir, S. A., Lin, S. S., Blue, L. J., Gockerman, J. P., Russell, S. D., Milano, C. A.
(2005). Left Ventricular Assist Device as Destination Therapy in Doxorubicin-Induced Cardiomyopathy. Ann. Thorac. Surg.
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[Abstract][Full Text]
Sandri, M. T., Salvatici, M., Cardinale, D., Zorzino, L., Passerini, R., Lentati, P., Leon, M., Civelli, M., Martinelli, G., Cipolla, C. M.
(2005). N-Terminal Pro-B-Type Natriuretic Peptide after High-Dose Chemotherapy: A Marker Predictive of Cardiac Dysfunction?. Clin. Chem.
51: 1405-1410
[Abstract][Full Text]
Chicco, A. J., Schneider, C. M., Hayward, R.
(2005). Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart. Am. J. Physiol. Regul. Integr. Comp. Physiol.
289: R424-R431
[Abstract][Full Text]
Hayek, E. R., Speakman, E., Rehmus, E.
(2005). Acute Doxorubicin Cardiotoxicity. NEJM
352: 2456-2457
[Full Text]
Peng, X., Chen, B., Lim, C. C., Sawyer, D. B.
(2005). The Cardiotoxicology of Anthracycline Chemotherapeutics: TRANSLATING MOLECULAR MECHANISM INTO PREVENTATIVE MEDICINE. Mol. Interv.
5: 163-171
[Abstract][Full Text]
Kilickap, S., Barista, I., Akgul, E., Aytemir, K., Aksoyek, S., Aksoy, S., Celik, I., Kes, S., Tekuzman, G.
(2005). cTnT can be a useful marker for early detection of anthracycline cardiotoxicity. Ann Oncol
16: 798-804
[Abstract][Full Text]
Fisher, P. W., Salloum, F., Das, A., Hyder, H., Kukreja, R. C.
(2005). Phosphodiesterase-5 Inhibition With Sildenafil Attenuates Cardiomyocyte Apoptosis and Left Ventricular Dysfunction in a Chronic Model of Doxorubicin Cardiotoxicity. Circulation
111: 1601-1610
[Abstract][Full Text]
Lou, H., Danelisen, I., Singal, P. K.
(2005). Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy. Am. J. Physiol. Heart Circ. Physiol.
288: H1925-H1930
[Abstract][Full Text]
Lakhman, S. S., Ghosh, D., Blanco, J. G.
(2005). FUNCTIONAL SIGNIFICANCE OF A NATURAL ALLELIC VARIANT OF HUMAN CARBONYL REDUCTASE 3 (CBR3). Drug Metab. Dispos.
33: 254-257
[Abstract][Full Text]
Keller, A. M., Mennel, R. G., Georgoulias, V. A., Nabholtz, J.-M., Erazo, A., Lluch, A., Vogel, C. L., Kaufmann, M., von Minckwitz, G., Henderson, I. C., Mellars, L., Alland, L., Tendler, C.
(2004). Randomized Phase III Trial of Pegylated Liposomal Doxorubicin Versus Vinorelbine or Mitomycin C Plus Vinblastine in Women With Taxane-Refractory Advanced Breast Cancer. JCO
22: 3893-3901
[Abstract][Full Text]
Lillig, C. H., Lonn, M. E., Enoksson, M., Fernandes, A. P., Holmgren, A.
(2004). Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide. Proc. Natl. Acad. Sci. USA
101: 13227-13232
[Abstract][Full Text]
Bonneterre, J., Roche, H., Kerbrat, P., Fumoleau, P., Goudier, M.-J., Fargeot, P., Montcuquet, P., Clavere, P., Barats, J.-C., Monnier, A., Veyret, C., Datchary, J., Van Praagh, I., Chapelle-Marcillac, I.
(2004). Long-Term Cardiac Follow-Up in Relapse-Free Patients After Six Courses of Fluorouracil, Epirubicin, and Cyclophosphamide, With Either 50 or 100 mg of Epirubicin, As Adjuvant Therapy for Node-Positive Breast Cancer: French Adjuvant Study Group. JCO
22: 3070-3079
[Abstract][Full Text]
Wang, S., Konorev, E. A., Kotamraju, S., Joseph, J., Kalivendi, S., Kalyanaraman, B.
(2004). Doxorubicin Induces Apoptosis in Normal and Tumor Cells via Distinctly Different Mechanisms: INTERMEDIACY OF H2O2- AND p53-DEPENDENT PATHWAYS. J. Biol. Chem.
279: 25535-25543
[Abstract][Full Text]
Minotti, G., Menna, P., Salvatorelli, E., Cairo, G., Gianni, L.
(2004). Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity. Pharmacol. Rev.
56: 185-229
[Abstract][Full Text]
Aries, A., Paradis, P., Lefebvre, C., Schwartz, R. J., Nemer, M.
(2004). Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity. Proc. Natl. Acad. Sci. USA
101: 6975-6980
[Abstract][Full Text]
Yan, Z., Zak, R., Zhang, Y., Ding, W., Godwin, S., Munson, K., Peluso, R., Engelhardt, J. F.
(2004). Distinct Classes of Proteasome-Modulating Agents Cooperatively Augment Recombinant Adeno-Associated Virus Type 2 and Type 5-Mediated Transduction from the Apical Surfaces of Human Airway Epithelia. J. Virol.
78: 2863-2874
[Abstract][Full Text]
Cresta, S., Grasselli, G., Mansutti, M., Martoni, A., Lelli, G., Capri, G., Buzzi, F., Robustelli Della Cuna, G., Jirillo, A., Terzoli, E., Frevola, L., Tarenzi, E., Sguotti, C., Azli, N., Murawsky, M., Gianni, L.
(2004). A randomized phase II study of combination, alternating and sequential regimens of doxorubicin and docetaxel as first-line chemotherapy for women with metastatic breast cancer. Ann Oncol
15: 433-439
[Abstract][Full Text]
O'Brien, M. E. R., Wigler, N., Inbar, M., Rosso, R., Grischke, E., Santoro, A., Catane, R., Kieback, D. G., Tomczak, P., Ackland, S. P., Orlandi, F., Mellars, L., Alland, L., Tendler, C.
(2004). Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYXTM/Doxil(R)) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann Oncol
15: 440-449
[Abstract][Full Text]
Gatzemeier, U., Groth, G., Butts, C., Van Zandwijk, N., Shepherd, F., Ardizzoni, A., Barton, C., Ghahramani, P., Hirsh, V.
(2004). Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer. Ann Oncol
15: 19-27
[Abstract][Full Text]
Bianchi, G., Albanell, J., Eiermann, W., Vitali, G., Borquez, D., Vigano, L., Molina, R., Raab, G., Locatelli, A., Vanhauwere, B., Gianni, L., Baselga, J.
(2003). Pilot Trial of Trastuzumab Starting with or after the Doxorubicin Component of a Doxorubicin plus Paclitaxel Regimen for Women with HER2-Positive Advanced Breast Cancer. Clin. Cancer Res.
9: 5944-5951
[Abstract][Full Text]
Lebrecht, D., Setzer, B., Ketelsen, U.-P., Haberstroh, J., Walker, U. A.
(2003). Time-Dependent and Tissue-Specific Accumulation of mtDNA and Respiratory Chain Defects in Chronic Doxorubicin Cardiomyopathy. Circulation
108: 2423-2429
[Abstract][Full Text]
Olson, L. E., Bedja, D., Alvey, S. J., Cardounel, A. J., Gabrielson, K. L., Reeves, R. H.
(2003). Protection from Doxorubicin-Induced Cardiac Toxicity in Mice with a Null Allele of Carbonyl Reductase 1. Cancer Res.
63: 6602-6606
[Abstract][Full Text]
Miranda, C. J., Makui, H., Soares, R. J., Bilodeau, M., Mui, J., Vali, H., Bertrand, R., Andrews, N. C., Santos, M. M.
(2003). Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin. Blood
102: 2574-2580
[Abstract][Full Text]
Swift, L., McHowat, J., Sarvazyan, N.
(2003). Inhibition of Membrane-associated Calcium-independent Phospholipase A2 as a Potential Culprit of Anthracycline Cardiotoxicity. Cancer Res.
63: 5992-5998
[Abstract][Full Text]
Navari, R. M, Koeller, J. M
(2003). Electrocardiographic and Cardiovascular Effects of the 5-Hydroxytryptamine3 Receptor Antagonists. The Annals of Pharmacotherapy
37: 1276-1286
[Abstract][Full Text]
Not, T., Faleschini, E., Tommasini, A., Repetto, A., Pasotti, M., Baldas, V., Spano, A., Sblattero, D., Marzari, R., Campana, C., Gavazzi, A., Tavazzi, L., Biagi, F., Roberto Corazza, G., Ventura, A., Arbustini, E.
(2003). Celiac disease in patients with sporadic and inherited cardiomyopathies and in their relatives. Eur Heart J
24: 1455-1461
[Abstract][Full Text]
Heon, S., Bernier, M., Servant, N., Dostanic, S., Wang, C., Kirby, G. M., Alpert, L., Chalifour, L. E.
(2003). Dexrazoxane does not protect against doxorubicin-induced damage in young rats. Am. J. Physiol. Heart Circ. Physiol.
285: H499-H506
[Abstract][Full Text]
Poutanen, T., Tikanoja, T., Riikonen, P., Silvast, A., Perkkio, M.
(2003). Long-Term Prospective Follow-Up Study of Cardiac Function After Cardiotoxic Therapy for Malignancy in Children. JCO
21: 2349-2356
[Abstract][Full Text]
Balachandar, A V, Malarkodi, K P, Varalakshmi, P
(2003). Protective role of DLa-lipoic acid against adriamycin-induced cardiac lipid peroxidation. Hum Exp Toxicol
22: 249-254
[Abstract]
Pacher, P., Liaudet, L., Bai, P., Mabley, J. G., Kaminski, P. M., Virag, L., Deb, A., Szabo, E., Ungvari, Z., Wolin, M. S., Groves, J. T., Szabo, C.
(2003). Potent Metalloporphyrin Peroxynitrite Decomposition Catalyst Protects Against the Development of Doxorubicin-Induced Cardiac Dysfunction. Circulation
107: 896-904
[Abstract][Full Text]
Limat, S., Demesmay, K., Voillat, L., Bernard, Y., Deconinck, E., Brion, A., Sabbah, A., Woronoff-Lemsi, M. C., Cahn, J. Y.
(2003). Early cardiotoxicity of the CHOP regimen in aggressive non-Hodgkin's lymphoma. Ann Oncol
14: 277-281
[Abstract][Full Text]
Kim, Y., Ma, A.-G., Kitta, K., Fitch, S. N., Ikeda, T., Ihara, Y., Simon, A. R., Evans, T., Suzuki, Y. J.
(2003). Anthracycline-Induced Suppression of GATA-4 Transcription Factor: Implication in the Regulation of Cardiac Myocyte Apoptosis. Mol. Pharmacol.
63: 368-377
[Abstract][Full Text]
Nitobe, J., Yamaguchi, S., Okuyama, M., Nozaki, N., Sata, M., Miyamoto, T., Takeishi, Y., Kubota, I., Tomoike, H.
(2003). Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes. Cardiovasc Res
57: 119-128
[Abstract][Full Text]
Shioji, K., Kishimoto, C., Nakamura, H., Masutani, H., Yuan, Z., Oka, S.-i., Yodoi, J.
(2002). Overexpression of Thioredoxin-1 in Transgenic Mice Attenuates Adriamycin-Induced Cardiotoxicity. Circulation
106: 1403-1409
[Abstract][Full Text]
Childs, A. C., Phaneuf, S. L., Dirks, A. J., Phillips, T., Leeuwenburgh, C.
(2002). Doxorubicin Treatment in Vivo Causes Cytochrome c Release and Cardiomyocyte Apoptosis, As Well As Increased Mitochondrial Efficiency, Superoxide Dismutase Activity, and Bcl-2:Bax Ratio. Cancer Res.
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[Abstract][Full Text]
Suter, T. M., Meier, B.
(2002). Detection of anthracycline-induced cardiotoxicity: is there light at the end of the tunnel?. Ann Oncol
13: 647-649
[Full Text]
Jensen, B. V., Skovsgaard, T., Nielsen, S. L.
(2002). Functional monitoring of anthracycline cardiotoxicity: a prospective, blinded, long-term observational study of outcome in 120 patients. Ann Oncol
13: 699-709
[Abstract][Full Text]
Bash-Babula, J., Toppmeyer, D., Labassi, M., Reidy, J., Orlick, M., Senzon, R., Alli, E., Kearney, T., August, D., Shih, W., Yang, J.-M., Hait, W. N.
(2002). A Phase I/Pilot Study of Sequential Doxorubicin/Vinorelbine: Effects on p53 and Microtubule-associated Protein 4. Clin. Cancer Res.
8: 1057-1064
[Abstract][Full Text]
Lorenzo, E., Ruiz-Ruiz, C., Quesada, A. J., Hernandez, G., Rodriguez, A., Lopez-Rivas, A., Redondo, J. M.
(2002). Doxorubicin Induces Apoptosis and CD95 Gene Expression in Human Primary Endothelial Cells through a p53-dependent Mechanism. J. Biol. Chem.
277: 10883-10892
[Abstract][Full Text]
Seidman, A., Hudis, C., Pierri, M. K., Shak, S., Paton, V., Ashby, M., Murphy, M., Stewart, S. J., Keefe, D.
(2002). Cardiac Dysfunction in the Trastuzumab Clinical Trials Experience. JCO
20: 1215-1221
[Abstract][Full Text]
Pacher, P., Liaudet, L., Bai, P., Virag, L., Mabley, J. G., Hasko, G., Szabo, C.
(2002). Activation of Poly(ADP-Ribose) Polymerase Contributes to Development of Doxorubicin-Induced Heart Failure. J. Pharmacol. Exp. Ther.
300: 862-867
[Abstract][Full Text]
Tu, V. C., Bahl, J. J., Chen, Q. M.
(2002). Signals of Oxidant-Induced Cardiomyocyte Hypertrophy: Key Activation of p70 S6 Kinase-1 and Phosphoinositide 3-Kinase. J. Pharmacol. Exp. Ther.
300: 1101-1110
[Abstract][Full Text]
Keefe, D. L.
(2002). The Cardiotoxic Potential of the 5-HT3 Receptor Antagonist Antiemetics: Is There Cause for Concern?. The Oncologist
7: 65-72
[Abstract][Full Text]
Kalivendi, S. V., Kotamraju, S., Zhao, H., Joseph, J., Kalyanaraman, B.
(2001). Doxorubicin-induced Apoptosis Is Associated with Increased Transcription of Endothelial Nitric-oxide Synthase. EFFECT OF ANTIAPOPTOTIC ANTIOXIDANTS AND CALCIUM. J. Biol. Chem.
276: 47266-47276
[Abstract][Full Text]
Partridge, A. H., Burstein, H. J., Winer, E. P.
(2001). Side Effects of Chemotherapy and Combined Chemohormonal Therapy in Women With Early-Stage Breast Cancer. J Natl Cancer Inst Monogr
2001: 135-142
[Abstract][Full Text]
Rabelo, E., De Angelis, K., Bock, P., Gatelli Fernandes, T., Cervo, F., Bello Klein, A., Clausell, N., Claudia Irigoyen, M.
(2001). Baroreflex Sensitivity and Oxidative Stress in Adriamycin-Induced Heart Failure. Hypertension
38: 576-580
[Abstract][Full Text]
Meinardi, M.T., van Veldhuisen, D.J., Gietema, J.A., Dolsma, W.V., Boomsma, F., van den Berg, M.P., Volkers, C., Haaksma, J., de Vries, E.G.E., Sleijfer, D.Th., van der Graaf, W.T.A.
(2001). Prospective Evaluation of Early Cardiac Damage Induced by Epirubicin-Containing Adjuvant Chemotherapy and Locoregional Radiotherapy in Breast Cancer Patients. JCO
19: 2746-2753
[Abstract][Full Text]
Doroshow, J. H., Synold, T. W., Somlo, G., Akman, S. A., Gajewski, E.
(2001). Oxidative DNA base modifications in peripheral blood mononuclear cells of patients treated with high-dose infusional doxorubicin. Blood
97: 2839-2845
[Abstract][Full Text]
Khaper, N., Singal, P. K.
(2001). Modulation of oxidative stress by a selective inhibition of angiotensin II type 1 receptors in MI rats. J Am Coll Cardiol
37: 1461-1466
[Abstract][Full Text]
Sun, X., Zhou, Z., Kang, Y. J.
(2001). Attenuation of Doxorubicin Chronic Toxicity in Metallothionein-overexpressing Transgenic Mouse Heart. Cancer Res.
61: 3382-3387
[Abstract][Full Text]
Wong, B. K., DeFeo-Jones, D., Jones, R. E., Garsky, V. M., Feng, D.-M., Oliff, A., Chiba, M., Ellis, J. D., Lin, J. H.
(2001). PSA-Specific and Non-PSA-Specific Conversion of a PSA-Targeted Peptide Conjugate of Doxorubicin to Its Active Metabolites. Drug Metab. Dispos.
29: 313-318
[Abstract][Full Text]
Feldman, A. M., McNamara, D.
(2000). Myocarditis. NEJM
343: 1388-1398
[Full Text]
Li, T., Singal, P. K.
(2000). Adriamycin-Induced Early Changes in Myocardial Antioxidant Enzymes and Their Modulation by Probucol. Circulation
102: 2105-2110
[Abstract][Full Text]
Feldman, A. M., Lorell, B. H., Reis, S. E.
(2000). Trastuzumab in the Treatment of Metastatic Breast Cancer : Anticancer Therapy Versus Cardiotoxicity. Circulation
102: 272-274
[Abstract][Full Text]
Li, T., Danelisen, I., Bello-Klein, A., Singal, P. K.
(2000). Effects of probucol on changes of antioxidant enzymes in adriamycin-induced cardiomyopathy in rats. Cardiovasc Res
46: 523-530
[Abstract][Full Text]
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