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Previous Volume 339:917-918 September 24, 1998 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The familiar triad of pathogens responsible for most cases of bacterial meningitis was first shown to yield to treatment with -lactam antibiotics and chloramphenicol over four decades ago. Chloramphenicol proved to be an effective alternative for the treatment of pneumococcal and meningococcal disease in patients who were allergic to penicillin and was particularly effective in treating meningitis caused by Haemophilus influenzae. Chloramphenicol's loss of favor began in the 1960s, when it was shown to have two distinct toxic effects on hematopoiesis: a frequently observed, dose-dependent anemia, reversible on cessation of therapy, and an irreversible, "idiosyncratic" aplastic anemia, which had an . . . [Full Text of this Article]

References

This article has been cited by other articles:

• (1998). Chloramphenicol Resistance in N. meningitidis. JWatch Infect. Diseases 1998: 5-5 [Full Text]