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Correspondence
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Volume 339:923-924 September 24, 1998 Number 13
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Cancer among Offspring of Survivors of Childhood Cancer

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by Sankila, R.
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To the Editor: In the article by Sankila et al. (May 7 issue)1 on the occurrence of cancer among the offspring of childhood-cancer survivors, a total of 44 cancers were diagnosed among 5847 offspring of 14,652 survivors. After excluding 22 cases associated with familial cancer syndromes (retinoblastoma and the Li–Fraumeni syndrome) or predisposing genetic conditions (neurofibromatosis and von Hippel–Lindau disease), the authors calculated a standardized incidence ratio of 1.3 (95 percent confidence interval, 0.8 to 2.0). Sankila et al. suggest that there was no evidence of an increased risk of nonhereditary cancer among the offspring of survivors of childhood cancer. . . . [Full Text of this Article]

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