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Previous Volume 339:924-925 September 24, 1998 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Aaltonen, L. A. Related Article by Dighiero, G.

To the Editor: Although I agree with Aaltonen et al. (May 21 issue)¹ that there is a need for a reliable diagnostic test for hereditary nonpolyposis colorectal cancer, I am concerned about their recommendations. To propose testing for replication errors (and if positive, subsequent testing for mutations of DNA mismatch-repair genes) in all patients with colorectal cancer who meet specific criteria may be premature and perhaps appropriate only as part of a research protocol.

The authors cite the conclusion by Vasen et al.² — "carriers of mismatch-repair gene mutations have a greater than 80 percent risk of cancer by the . . . [Full Text of this Article]

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