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Correspondence
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Volume 339:1163-1165 October 15, 1998 Number 16
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Tirofiban in Unstable Coronary Disease

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-Related Article
 by The Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) Study Investigators
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 by The Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Study Investigators
-PubMed Citation
To the Editor: The Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) and Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) studies (May 21 issue)1,2 left me confused. The studies were conducted almost simultaneously, but they found different results with the use of tirofiban alone, which were not adequately explained by the editorialists.3 There was no effect of tirofiban alone in the PRISM-PLUS study (treatment in this group was in fact stopped early), whereas in the PRISM study tirofiban alone was suggested as a treatment option. Is there an explanation for these . . . [Full Text of this Article]

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