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Editorial
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Volume 339:1238-1239 October 22, 1998 Number 17
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The Quest for a Bone Marrow Donor — Optimal or Maximal HLA Matching?

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 by Sasazuki, T.
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 by Aversa, F.
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Bone marrow transplantation was first used successfully exactly 30 years ago, in children with congenital immune deficiencies.1 The demonstration that bone marrow transplantation was also effective in treating aplastic anemia and malignant hematologic disorders followed a few years later. Its use for other indications, such as metastatic breast cancer and certain autoimmune diseases, is being explored. Annually, more than 30,000 patients undergo transplantation with bone marrow from a related or an unrelated donor (allogeneic transplantation) or with the patient's own, previously stored marrow (autologous transplantation). The results of marrow transplantations have steadily improved, but many patients receiving an allograft die . . . [Full Text of this Article]

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