FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 339:114-115 July 9, 1998 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Lai, C.-L. PubMed Citation

In this issue of the Journal, Lai et al.¹ report the results of a one-year trial of lamivudine, an oral nucleoside analogue, in patients with chronic hepatitis B infection. The 358 patients were randomly assigned to receive daily lamivudine (25 mg or 100 mg) or placebo orally for one year. The incidence of adverse events was similar in all groups and there were few serious adverse events. Histologic improvements, including a reduction in necroinflammatory activity and fibrosis, were demonstrated in the patients treated with lamivudine, as compared with those receiving placebo. The patients treated with 100 mg of lamivudine had . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Lin, C-L, Tsai, S-L, Lee, T-H, Chien, R-N, Liao, S-K, Liaw, Y-F (2005). High frequency of functional anti-YMDD and -mutant cytotoxic T lymphocytes after in vitro expansion correlates with successful response to lamivudine therapy for chronic hepatitis B. Gut 54: 152-161 [Abstract] [Full Text]  
• Ho, S. K.N., Yam, W.-C., Leung, E. T.K., Wong, L.-P., Leung, J. K.H., Lai, K.-N., Chan, T.-M. (2003). Rapid quantification of hepatitis B virus DNA by real-time PCR using fluorescent hybridization probes. J Med Microbiol 52: 397-402 [Abstract] [Full Text]  
• Ono-Nita, S. K., Kato, N., Shiratori, Y., Carrilho, F. J., Omata, M. (2002). Novel Nucleoside Analogue MCC-478 (LY582563) Is Effective against Wild-Type or Lamivudine-Resistant Hepatitis B Virus. Antimicrob. Agents Chemother. 46: 2602-2605 [Abstract] [Full Text]  
• Dufour, D. R., Lott, J. A., Nolte, F. S., Gretch, D. R., Koff, R. S., Seeff, L. B. (2000). Diagnosis and Monitoring of Hepatic Injury. II. Recommendations for Use of Laboratory Tests in Screening, Diagnosis, and Monitoring. Clin. Chem. 46: 2050-2068 [Abstract] [Full Text]