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Previous Volume 339:130-131 July 9, 1998 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their excellent review of alcohol problems, O'Connor and Schottenfeld (Feb. 26 issue)¹ discuss several ways to treat the alcohol withdrawal syndrome. Although infrequently used therapies such as carbamazepine are considered, the authors do not mention chlormethiazole (clomethiazole), a derivative of vitamin B₁ with sedative and anticonvulsant properties, which is widely used in Europe but not approved for use in the United States.² Like benzodiazepines, chlormethiazole can cause respiratory depression, which is the main factor limiting its use. It controls agitation and seizures effectively. The availability of solutions containing 4 g of chlormethiazole in 500 ml of . . . [Full Text of this Article]

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