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Previous Volume 339:134-135 July 9, 1998 Number 2 Next

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By Gina Kolata. 276 pp. New York, William Morrow, 1998. $23. ISBN 0-688-15692-4.
By Lee M. Silver. 317 pp. New York, Avon Books, 1997. $25. ISBN 0-380-97494-0.

On February 27, 1997, Ian Wilmut and his colleagues at an animal-husbandry research center near Edinburgh, Scotland, announced in Nature the birth of Dolly. This was no mere birth notice: Dolly was produced by fusing the nucleus of a cell from the udder of a six-year-old sheep with an unfertilized, nucleus-free egg from another sheep. For the first time, the restricted genetic information in the nucleus of a differentiated mammalian cell was reprogrammed to reveal everything it knew about forming all the other cells of the body. In effect, cellular time was reversed — a terminally differentiated cell reverted to . . . [Full Text of this Article]

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