In this issue of the Journal, Wade and colleagues1 present dataon the outcomes of short, prophylactic courses of zidovudineadministered to infants born to women infected with the humanimmunodeficiency virus (HIV) who presented for obstetrical carein New York State between 1995 and 1997. Their report containssome reassuring and confirmatory information, as well as somesurprising and provocative new observations. The pathophysiologicand therapeutic basis for the study involves both the timingof the vertical transmission of HIV and the prophylactic roleof zidovudine in this setting.
Short Courses of Zidovudine and Perinatal Transmission of HIV
Fiscus S. A., Schoenbach V. J., Wilfert C., Thomas P., Bornschlegel K., Feiterna-Sperling C., Maier R. F., Grosch-Wörner I., Shaffer N., Bulterys M., Simonds R.J., Wade N. A., Birkhead G. S., French P. T.
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N Engl J Med 1999;
340:1040-1043, Apr 1, 1999.
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Fiscus, S. A., Schoenbach, V. J., Wilfert, C., Thomas, P., Bornschlegel, K., Feiterna-Sperling, C., Maier, R. F., Grosch-Worner, I., Shaffer, N., Bulterys, M., Simonds, R.J., Wade, N. A., Birkhead, G. S., French, P. T.
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