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Volume 339:1475-1477 November 12, 1998 Number 20
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Treatment of Intermediate-Grade and High-Grade Non-Hodgkin's Lymphoma

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 by Cosset, J.M.
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 by Miller, T. P.
To the Editor: Miller et al. (July 2 issue)1 are to be commended on their report of the randomized trial comparing full-dose chemotherapy with limited chemotherapy and involved-field radiation for the treatment of localized intermediate-grade and high-grade non-Hodgkin's lymphoma. Previously, the management of this condition with chemotherapy and radiotherapy has been based on retrospective reports and small phase 2 studies and has been the subject of some controversy.2

Miller et al. demonstrated that three cycles of chemotherapy followed by involved-field radiotherapy, as compared with eight cycles of chemotherapy alone, resulted in an improvement of 10 percentage points in the estimated . . . [Full Text of this Article]

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