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Correspondence
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Volume 339:1640-1642 November 26, 1998 Number 22
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Association of Mutations in the Apolipoprotein B Gene with Hypercholesterolemia and the Risk of Ischemic Heart Disease

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by Tybjærg-Hansen, A.
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To the Editor: We disagree with several of the conclusions of Tybjærg-Hansen et al. (May 28 issue)1 concerning the clinical significance of mutations in the apolipoprotein B gene with respect to lipoprotein metabolism. First, the failure to identify persons with the Arg3500Trp mutation in a Scandinavian population cannot justify disregarding this mutation in others. Other studies have found 6 subjects with the Arg3500Trp mutation and 29 subjects with the Arg3500Gln mutation2,3 (and unpublished data). Second, Boren et al.4 have shown that the presence of an arginine at residue 3500 is crucial. Third, data on two families showed that the Arg3500Trp . . . [Full Text of this Article]

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