In patients under the age of 60 who have acute myeloid leukemia,chemotherapy now routinely produces a complete remission in70 to 80 percent of cases.1,2 Since it is generally acceptedthat survival is poor if relapse occurs, the priority is tomake the most of the remission. Patients in this age group havethree options after they enter remission.
If an HLA-matched sibling donor is available, allogeneic hematopoieticstem-cell transplantation is usually chosen. This strategy offersa 50 to 60 percent chance of cure; it became standard treatmentin the early 1980s, when the five-year survival with chemotherapywas . . . [Full Text of this Article]
References
This article has been cited by other articles:
Jabbour, E. J., Estey, E., Kantarjian, H. M.
(2006). Adult Acute Myeloid Leukemia. Mayo Clin Proc.
81: 247-260
[Abstract][Full Text]
Woods, W. G., Neudorf, S., Gold, S., Sanders, J., Buckley, J. D., Barnard, D. R., Dusenbery, K., DeSwarte, J., Arthur, D. C., Lange, B. J., Kobrinsky, N. L.
(2001). A comparison of allogeneic bone marrow transplantation, autologous bone marrow transplantation, and aggressive chemotherapy in children with acute myeloid leukemia in remission: a report from the Children's Cancer Group. Blood
97: 56-62
[Abstract][Full Text]
Harousseau, J. L., Witz, B., Lioure, B., Hunault-Berger, M., Desablens, B., Delain, M., Guilhot, F., Le Prise, P. Y., Abgrall, J. F., Deconinck, E., Guyotat, D., Vilque, J. P., Casassus, P., Tournilhac, O., Audhuy, B., Solary, E.
(2000). Granulocyte Colony-Stimulating Factor After Intensive Consolidation Chemotherapy in Acute Myeloid Leukemia: Results of a Randomized Trial of the Groupe Ouest-Est Leucemies Aigues Myeloblastiques. JCO
18: 780-780
[Abstract][Full Text]
Kanda, Y., Miwa, A., Togawa, A., Perez-Calvo, J., Brugarolas, A., Suzuki, R., Seto, M., Morishima, Y., Gorin, N.-C., Labopin, M., Woods, W. G., Sanders, J. E., Neudorf, S., Cassileth, P. A., Appelbaum, F. R., Wiernik, P. H., Burnett, A. K.
(1999). Treatment of Acute Myeloid Leukemia. NEJM
340: 1436-1439
[Full Text]