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Correspondence
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Volume 339:1783-1786 December 10, 1998 Number 24
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Exercise-Induced Asthma

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 by Hansen-Flaschen, J.
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 by Nelson, J. A.
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 by Leff, J. A.
To the Editor: In the study of long-term salmeterol treatment for exercise-induced asthma reported by Nelson et al. (July 16 issue),1 a flaw in the procedure for selecting patients was that not all subjects were receiving concurrent therapy with inhaled corticosteroids, in accordance with asthma-management guidelines. In real life, moreover, patients normally take a {beta}2-adrenergic agonist on an occasional basis before engaging in exercise.

The authors state that they chose to use exercise because it is an example of a clinically relevant bronchoconstrictor stimulus. Since the inhalation of cold air augments the bronchoconstrictor response to exercise,2 the exercise protocol they . . . [Full Text of this Article]

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