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Previous Volume 339:1856-1857 December 17, 1998 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The study by Dreifuss et al. (June 25 issue)¹ comparing rectal diazepam gel with placebo for the treatment of acute repetitive seizures raises the issue of whether the use of placebos in studies of serious illness for which accepted therapy exists is ethical.² Apparently, the institutional review boards at the 11 institutions involved believed that "regular review" by an independent monitoring board and a single unblinded interim analysis provided adequate protection for children and adults with recent episodes of acute repetitive seizures who were randomly assigned to receive placebo, even though as the authors point out, "left . . . [Full Text of this Article]

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