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Previous Volume 339:194-195 July 16, 1998 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Animal models of sickle cell anemia can be used to improve understanding of the pathophysiology of the disease, aid in the development of antisickling drugs, and test the feasibility of gene therapy. The basis of these interesting models is transgenic technology, in which foreign genes are introduced into the germ line of a mouse. With this method it is possible to create mice that carry the mutant sickle, or S, gene and a normal human -globin gene. In such animals, the human S and -globin genes code for sickle hemoglobin (₂S₂), but they also coexist with murine . . . [Full Text of this Article]

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