FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 339:321-328 July 30, 1998 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

In 1981, de Bold and his colleagues made the seminal observation that infusion of extracts of atrial tissue into rats caused a copious natriuresis.¹ This then led to the isolation and cloning of atrial natriuretic peptide, the first member of a family of peptides with potent natriuretic, diuretic, and vasorelaxant activity.² Subsequent contributions from many investigators have expanded our understanding of the family of natriuretic peptides, their receptors, and their cellular actions that regulate physiologic functions. Studies using drugs to inhibit the function of some natriuretic peptide receptors or to prevent the degradation of natriuretic peptides have confirmed the importance . . . [Full Text of this Article]

Biochemistry and Molecular Biology

Natriuretic Peptide Receptors

Guanylyl Cyclase Receptors

Natriuretic Peptide–Clearance Receptor

Actions of Natriuretic Peptides

Cardiovascular Actions

Renal Actions

Actions on the Central Nervous System

Pathophysiology

Cardiovascular Disease

Hypertension

Therapeutic Uses

Conclusions

Source Information

From the Departments of Medicine and Pharmacology, University of California, Irvine, and the Veterans Affairs Medical Center, Long Beach, Calif. (E.R.L.); the Department of Medicine and the Metabolic Research Unit, University of California, San Francisco (D.G.G.); and the Department of Physiology, University of North Dakota School of Medicine, Grand Forks (W.K.S.).

Address reprint requests to Dr. Levin at the Long Beach Veterans Hospital, Medical Service (111-I), 5901 E. 7th St., Long Beach, CA 90822.

References

This article has been cited by other articles:

• Moro, C., Smith, S. R. (2009). Natriuretic Peptides: New Players in Energy Homeostasis. Diabetes 58: 2726-2728 [Full Text]  
• Lara-Castillo, N., Zandi, S., Nakao, S., Ito, Y., Noda, K., She, H., Ahmed, M., Frimmel, S., Ablonczy, Z., Hafezi-Moghadam, A. (2009). Atrial Natriuretic Peptide Reduces Vascular Leakage and Choroidal Neovascularization. Am. J. Pathol. 175: 2343-2350 [Abstract] [Full Text]  
• Di Angelantonio, E., Chowdhury, R., Sarwar, N., Ray, K. K., Gobin, R., Saleheen, D., Thompson, A., Gudnason, V., Sattar, N., Danesh, J. (2009). B-Type Natriuretic Peptides and Cardiovascular Risk: Systematic Review and Meta-Analysis of 40 Prospective Studies. Circulation 120: 2177-2187 [Abstract] [Full Text]  
• Patton, K. K., Ellinor, P. T., Heckbert, S. R., Christenson, R. H., DeFilippi, C., Gottdiener, J. S., Kronmal, R. A. (2009). N-Terminal Pro-B-Type Natriuretic Peptide Is a Major Predictor of the Development of Atrial Fibrillation: The Cardiovascular Health Study. Circulation 120: 1768-1774 [Abstract] [Full Text]  
• Karthikeyan, G., Moncur, R. A., Levine, O., Heels-Ansdell, D., Chan, M. T.V., Alonso-Coello, P., Yusuf, S., Sessler, D., Villar, J. C., Berwanger, O., McQueen, M., Mathew, A., Hill, S., Gibson, S., Berry, C., Yeh, H.-M., Devereaux, P.J. (2009). Is a pre-operative brain natriuretic peptide or N-terminal pro-B-type natriuretic peptide measurement an independent predictor of adverse cardiovascular outcomes within 30 days of noncardiac surgery? A systematic review and meta-analysis of observational studies.. J Am Coll Cardiol 54: 1599-1606 [Abstract] [Full Text]  
• Pizarro, R., Bazzino, O. O., Oberti, P. F., Falconi, M., Achilli, F., Arias, A., Krauss, J. G., Cagide, A. M. (2009). Prospective validation of the prognostic usefulness of brain natriuretic peptide in asymptomatic patients with chronic severe mitral regurgitation.. J Am Coll Cardiol 54: 1099-1106 [Abstract] [Full Text]  
• George, I., Morrow, B., Xu, K., Yi, G.-H., Holmes, J., Wu, E. X., Li, Z., Protter, A. A., Oz, M. C., Wang, J. (2009). Prolonged effects of B-type natriuretic peptide infusion on cardiac remodeling after sustained myocardial injury. Am. J. Physiol. Heart Circ. Physiol. 297: H708-H717 [Abstract] [Full Text]  
• Moro, C., Pasarica, M., Elkind-Hirsch, K., Redman, L. M. (2009). Aerobic Exercise Training Improves Atrial Natriuretic Peptide and Catecholamine-Mediated Lipolysis in Obese Women with Polycystic Ovary Syndrome. J. Clin. Endocrinol. Metab. 94: 2579-2586 [Abstract] [Full Text]  
• Choquet, H., Cavalcanti-Proenca, C., Lecoeur, C., Dina, C., Cauchi, S., Vaxillaire, M., Hadjadj, S., Horber, F., Potoczna, N., Charpentier, G., Ruiz, J., Hercberg, S., Maimaitiming, S., Roussel, R., Boenhnke, M., Jackson, A. U., Patsch, W., Krempler, F., Voight, B. F., Altshuler, D., Groop, L., Thorleifsson, G., Steinthorsdottir, V., Stefansson, K., Balkau, B., Froguel, P., Meyre, D. (2009). The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects. Hum Mol Genet 18: 2495-2501 [Abstract] [Full Text]  
• Kurl, S, Ala-Kopsala, M, Ruskoaho, H, Makikallio, T, Nyyssonen, K, Vuolteenaho, O, Sivenius, J, Salonen, J T, Laukkanen, J A (2009). Plasma N-terminal fragments of natriuretic peptides predict the risk of stroke and atrial fibrillation in men. Heart 95: 1067-1071 [Abstract] [Full Text]  
• Kumar, P., Pandey, K. N. (2009). Cooperative Activation of Npr1 Gene Transcription and Expression by Interaction of Ets-1 and p300. Hypertension 54: 172-178 [Abstract] [Full Text]  
• Tsukamoto, O., Fujita, M., Kato, M., Yamazaki, S., Asano, Y., Ogai, A., Okazaki, H., Asai, M., Nagamachi, Y., Maeda, N., Shintani, Y., Minamino, T., Asakura, M., Kishimoto, I., Funahashi, T., Tomoike, H., Kitakaze, M. (2009). Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure.. J Am Coll Cardiol 53: 2070-2077 [Abstract] [Full Text]  
• Boerrigter, G., Costello-Boerrigter, L. C., Harty, G. J., Huntley, B. K., Cataliotti, A., Lapp, H., Burnett, J. C. Jr. (2009). B-type natriuretic peptide 8-32, which is produced from mature BNP 1-32 by the metalloprotease meprin A, has reduced bioactivity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296: R1744-R1750 [Abstract] [Full Text]  
• Arejian, M., Li, Y., Anand-Srivastava, M. B. (2009). Nitric oxide attenuates the expression of natriuretic peptide receptor C and associated adenylyl cyclase signaling in aortic vascular smooth muscle cells: role of MAPK. Am. J. Physiol. Heart Circ. Physiol. 296: H1859-H1867 [Abstract] [Full Text]  
• Dhar, S, Pressman, G S, Subramanian, S, Kaul, S, Gollamudi, S, Bloom, E J, Figueredo, V M (2009). Natriuretic peptides and heart failure in the patient with chronic kidney disease: a review of current evidence. Postgrad. Med. J. 85: 299-302 [Abstract] [Full Text]  
• Lorgis, L, Zeller, M, Dentan, G, Sicard, P, Buffet, P, L'Huillier, I, Beer, J C, Vincent-Martin, M, Makki, H, Gambert, P, Cottin, Y, on behalf of the RICO Survey Working Group, (2009). Prognostic value of N-terminal pro-brain natriuretic peptide in elderly people with acute myocardial infarction: prospective observational study. BMJ 338: b1605-b1605 [Abstract] [Full Text]  
• Johnson, K. R., Olson, K. R. (2009). Responses of the trout cardiac natriuretic peptide system to manipulation of salt and water balance. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296: R1170-R1179 [Abstract] [Full Text]  
• Glenn, D. J., Wang, F., Chen, S., Nishimoto, M., Gardner, D. G. (2009). Endothelin-Stimulated Human B-Type Natriuretic Peptide Gene Expression Is Mediated by Yin Yang 1 in Association With Histone Deacetylase 2. Hypertension 53: 549-555 [Abstract] [Full Text]  
• Matias, P. J., Ferreira, C., Jorge, C., Borges, M., Aires, I., Amaral, T., Gil, C., Cortez, J., Ferreira, A. (2009). 25-Hydroxyvitamin D3, arterial calcifications and cardiovascular risk markers in haemodialysis patients. Nephrol Dial Transplant 24: 611-618 [Abstract] [Full Text]  
• Kelder, J. C, Rutten, F. H, Hoes, A. W (2009). Clinically relevant diagnostic research in primary care: the example of B-type natriuretic peptides in the detection of heart failure. Fam Pract 26: 69-74 [Abstract] [Full Text]  
• Chen, S., Glenn, D. J., Ni, W., Grigsby, C. L., Olsen, K., Nishimoto, M., Law, C. S., Gardner, D. G. (2008). Expression of the Vitamin D Receptor Is Increased in the Hypertrophic Heart. Hypertension 52: 1106-1112 [Abstract] [Full Text]  
• Niederkofler, E. E., Kiernan, U. A., O'Rear, J., Menon, S., Saghir, S., Protter, A. A., Nelson, R. W., Schellenberger, U. (2008). Detection of Endogenous B-Type Natriuretic Peptide at Very Low Concentrations in Patients With Heart Failure. Circ Heart Fail 1: 258-264 [Abstract] [Full Text]  
• Ray, P., Delerme, S., Jourdain, P., Chenevier-Gobeaux, C. (2008). Differential diagnosis of acute dyspnea: the value of B natriuretic peptides in the emergency department. QJM 101: 831-843 [Abstract] [Full Text]  
• Cataliotti, A., Chen, H. H., Schirger, J. A., Martin, F. L., Boerrigter, G., Costello-Boerrigter, L. C., James, K. D., Polowy, K., Miller, M. A., Malkar, N. B., Bailey, K. R., Burnett, J. C. Jr (2008). Chronic Actions of a Novel Oral B-Type Natriuretic Peptide Conjugate in Normal Dogs and Acute Actions in Angiotensin II-Mediated Hypertension. Circulation 118: 1729-1736 [Abstract] [Full Text]  
• Daniels, L. B., Laughlin, G. A., Clopton, P., Maisel, A. S., Barrett-Connor, E. (2008). Minimally Elevated Cardiac Troponin T and Elevated N-Terminal Pro-B-Type Natriuretic Peptide Predict Mortality in Older Adults: Results From the Rancho Bernardo Study. J Am Coll Cardiol 52: 450-459 [Abstract] [Full Text]  
• Bradshaw, K., Smith, M. (2008). Disorders of sodium balance after brain injury. Contin Educ Anaesth Crit Care Pain 8: 129-133 [Full Text]  
• Montaner, J., Perea-Gainza, M., Delgado, P., Ribo, M., Chacon, P., Rosell, A., Quintana, M., Palacios, M. E., Molina, C. A., Alvarez-Sabin, J. (2008). Etiologic Diagnosis of Ischemic Stroke Subtypes With Plasma Biomarkers. Stroke 39: 2280-2287 [Abstract] [Full Text]  
• Hodgson-Zingman, D. M., Karst, M. L., Zingman, L. V., Heublein, D. M., Darbar, D., Herron, K. J., Ballew, J. D., de Andrade, M., Burnett, J. C. Jr., Olson, T. M. (2008). Atrial Natriuretic Peptide Frameshift Mutation in Familial Atrial Fibrillation. NEJM 359: 158-165 [Abstract] [Full Text]  
• Chung, T, Lim, W-C, Sy, R, Cunningham, I, Trotman, J, Kritharides, L (2008). Subacute cardiac toxicity following autologous haematopoietic stem cell transplantation in patients with normal cardiac function. Heart 94: 911-918 [Abstract] [Full Text]  
• Kasama, S., Furuya, M., Toyama, T., Ichikawa, S., Kurabayashi, M. (2008). Effect of atrial natriuretic peptide on left ventricular remodelling in patients with acute myocardial infarction. Eur Heart J 29: 1485-1494 [Abstract] [Full Text]  
• Villar, I. C, Hobbs, A. J, Ahluwalia, A. (2008). Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor. J Endocrinol 197: 447-462 [Abstract] [Full Text]  
• Khan, S. Q., Dhillon, O., Kelly, D., Squire, I. B., Struck, J., Quinn, P., Morgenthaler, N. G., Bergmann, A., Davies, J. E., Ng, L. L. (2008). Plasma N-Terminal B-Type Natriuretic Peptide as an Indicator of Long-Term Survival After Acute Myocardial Infarction: Comparison With Plasma Midregional Pro-Atrial Natriuretic Peptide: The LAMP (Leicester Acute Myocardial Infarction Peptide) Study. J Am Coll Cardiol 51: 1857-1864 [Abstract] [Full Text]  
• Waldo, S. W., Beede, J., Isakson, S., Villard-Saussine, S., Fareh, J., Clopton, P., Fitzgerald, R. L., Maisel, A. S. (2008). Pro-B-Type Natriuretic Peptide Levels in Acute Decompensated Heart Failure. J Am Coll Cardiol 51: 1874-1882 [Abstract] [Full Text]  
• Yip, G. W (2008). B-type natriuretic peptide: a treatment, not a diagnostic marker. Heart 94: 542-544 [Full Text]  
• Horsthuis, T., Houweling, A. C., Habets, P. E.M.H., de Lange, F. J., el Azzouzi, H., Clout, D. E.W., Moorman, A. F.M., Christoffels, V. M. (2008). Distinct Regulation of Developmental and Heart Disease-Induced Atrial Natriuretic Factor Expression by Two Separate Distal Sequences. Circ. Res. 102: 849-859 [Abstract] [Full Text]  
• Hsu, J.-H., Oishi, P. E., Keller, R. L., Chikovani, O., Karl, T. R., Azakie, A., Adatia, I., Fineman, J. R. (2008). Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection.. J. Thorac. Cardiovasc. Surg. 135: 746-753 [Abstract] [Full Text]  
• Belo, N. O., Sairam, M. R., dos Reis, A. M. (2008). Impairment of the Natriuretic Peptide System in Follitropin Receptor Knockout Mice and Reversal by Estradiol: Implications for Obesity-Associated Hypertension in Menopause. Endocrinology 149: 1399-1406 [Abstract] [Full Text]  
• Khan, A. R., Birbach, M., Cohen, M. S., Ittenbach, R. F., Spray, T. L., Levy, R. J., Gaynor, J. W. (2008). Chronic Hypoxemia Increases Ventricular Brain Natriuretic Peptide Precursors in Neonatal Swine. Ann. Thorac. Surg. 85: 618-623 [Abstract] [Full Text]  
• Yan, A. T., Yan, R. T., Spinale, F. G., Afzal, R., Gunasinghe, H. R., Stroud, R. E., McKelvie, R. S., Liu, P. P. (2008). Relationships between plasma levels of matrix metalloproteinases and neurohormonal profile in patients with heart failure. Eur J Heart Fail 10: 125-128 [Abstract] [Full Text]  
• Rose, R. A., Giles, W. R. (2008). Natriuretic peptide C receptor signalling in the heart and vasculature. J. Physiol. 586: 353-366 [Abstract] [Full Text]  
• Walsh, R., Boyer, C., LaCorte, J., Parnell, V., Sison, C., Chowdhury, D., Ojamaa, K. (2008). N-terminal B-type natriuretic peptide levels in pediatric patients with congestive heart failure undergoing cardiac surgery. J. Thorac. Cardiovasc. Surg. 135: 98-105 [Abstract] [Full Text]  
• Therrien, J.-P., Pfutzner, W., Vogel, J. C. (2008). An Approach to Achieve Long-Term Expression in Skin Gene Therapy. Toxicol Pathol 36: 104-111 [Abstract] [Full Text]  
• Koch, A. M.E., Zink, S., Singer, H., Dittrich, S. (2008). B-type natriuretic peptide levels in patients with functionally univentricular hearts after total cavopulmonary connection. Eur J Heart Fail 10: 60-62 [Abstract] [Full Text]  
• Moffatt, P., Thomas, G., Sellin, K., Bessette, M.-C., Lafreniere, F., Akhouayri, O., St-Arnaud, R., Lanctot, C. (2007). Osteocrin Is a Specific Ligand of the Natriuretic Peptide Clearance Receptor That Modulates Bone Growth. J. Biol. Chem. 282: 36454-36462 [Abstract] [Full Text]  
• Conen, D., Glynn, R. J., Buring, J. E., Ridker, P. M, Zee, R. Y.L. (2007). Natriuretic Peptide Precursor A Gene Polymorphisms and Risk of Blood Pressure Progression and Incident Hypertension. Hypertension 50: 1114-1119 [Abstract] [Full Text]  
• Witteles, R. M., Kao, D., Christopherson, D., Matsuda, K., Vagelos, R. H., Schreiber, D., Fowler, M. B. (2007). Impact of Nesiritide on Renal Function in Patients With Acute Decompensated Heart Failure and Pre-Existing Renal Dysfunction: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Am Coll Cardiol 50: 1835-1840 [Abstract] [Full Text]  
• Nakano, T., Kado, H., Tachibana, T., Hinokiyama, K., Shiose, A., Kajimoto, M., Ando, Y. (2007). Excellent Midterm Outcome of Extracardiac Conduit Total Cavopulmonary Connection: Results of 126 Cases. Ann. Thorac. Surg. 84: 1619-1626 [Abstract] [Full Text]  
• Vellaichamy, E., Zhao, D., Somanna, N., Pandey, K. N. (2007). Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates ACE and AT1 receptor gene expression and signaling: role in cardiac hypertrophy. Physiol. Genomics 31: 193-202 [Abstract] [Full Text]  
• Liao, X., Wang, W., Chen, S., Wu, Q. (2007). Role of Glycosylation in Corin Zymogen Activation. J. Biol. Chem. 282: 27728-27735 [Abstract] [Full Text]  
• Pascual-Figal, D. A, Antolinos, M. J, Bayes-Genis, A., Casas, T., Nicolas, F., Valdes, M. (2007). B-type natriuretic peptide release in the coronary effluent after acute transient ischaemia in humans. Heart 93: 1077-1080 [Abstract] [Full Text]  
• Karabinos, I., Karvouni, E., Chiotinis, N., Papadopoulos, A., Simeonidis, P., Tsolas, O., Katritsis, D. (2007). Acute changes in N-terminal pro-brain natriuretic peptide induced by dobutamine stress echocardiography. Eur J Echocardiogr 8: 265-274 [Abstract] [Full Text]  
• Cortes, R., Rivera, M., Salvador, A., Bertomeu, V., de Burgos, F. G., Rosello-Lleti, E., Portoles, M., Paya, R., Martinez-Dolz, L., Climent, V. (2007). Variability of NT-proBNP plasma and urine levels in patients with stable heart failure: a 2-year follow-up study. Heart 93: 957-962 [Abstract] [Full Text]  
• Sangaralingham, S J., Tse, M Y., Pang, S. C (2007). Estrogen protects against the development of salt-induced cardiac hypertrophy in heterozygous proANP gene-disrupted mice. J Endocrinol 194: 143-152 [Abstract] [Full Text]  
• Zhao, D., Vellaichamy, E., Somanna, N. K., Pandey, K. N. (2007). Guanylyl cyclase/natriuretic peptide receptor-A gene disruption causes increased adrenal angiotensin II and aldosterone levels. Am. J. Physiol. Renal Physiol. 293: F121-F127 [Abstract] [Full Text]  
• Levy, D., Hwang, S.-J., Kayalar, A., Benjamin, E. J., Vasan, R. S., Parise, H., Larson, M. G., Wang, T. J., Selhub, J., Jacques, P. F., Vita, J. A., Keyes, M. J., Mitchell, G. F. (2007). Associations of Plasma Natriuretic Peptide, Adrenomedullin, and Homocysteine Levels With Alterations in Arterial Stiffness: The Framingham Heart Study. Circulation 115: 3079-3085 [Abstract] [Full Text]  
• Ahmed, W., Zafar, S., Alam, A. Y., Ahktar, N., Shah, M. A., Alpert, M. A. (2007). Plasma Levels of B-Type Natriuretic Peptide in Patients With Unstable Angina Pectoris or Acute Myocardial Infarction: Prognostic Significance and Therapeutic Implications. ANGIOLOGY 58: 269-274 [Abstract]  
• Ribatti, D., Conconi, M. T., Nussdorfer, G. G. (2007). Nonclassic Endogenous Novel Regulators of Angiogenesis. Pharmacol. Rev. 59: 185-205 [Abstract] [Full Text]  
• Meirhaeghe, A., Sandhu, M. S., McCarthy, M. I., de Groote, P., Cottel, D., Arveiler, D., Ferrieres, J., Groves, C. J., Hattersley, A. T., Hitman, G. A., Walker, M., Wareham, N. J., Amouyel, P. (2007). Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations. Hum Mol Genet 16: 1343-1350 [Abstract] [Full Text]  
• Wang, Y., de Waard, M. C., Sterner-Kock, A., Stepan, H., Schultheiss, H.-P., Duncker, D. J., Walther, T. (2007). Cardiomyocyte-restricted over-expression of C-type natriuretic peptide prevents cardiac hypertrophy induced by myocardial infarction in mice. Eur J Heart Fail 9: 548-557 [Abstract] [Full Text]  
• Marz, W., Tiran, B., Seelhorst, U., Wellnitz, B., Bauersachs, J., Winkelmann, B. R., Boehm, B. O. (2007). N-Terminal Pro-B-Type Natriuretic Peptide Predicts Total and Cardiovascular Mortality in Individuals with or without Stable Coronary Artery Disease: The Ludwigshafen Risk and Cardiovascular Health Study. Clin. Chem. 53: 1075-1083 [Abstract] [Full Text]  
• Villar, I. C., Panayiotou, C. M., Sheraz, A., Madhani, M., Scotland, R. S., Nobles, M., Kemp-Harper, B., Ahluwalia, A., Hobbs, A. J. (2007). Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor. Cardiovasc Res 74: 515-525 [Abstract] [Full Text]  
• Fonarow, G. C., Peacock, W. F., Phillips, C. O., Givertz, M. M., Lopatin, M., for the ADHERE Scientific Advisory Committee and I, (2007). Admission B-Type Natriuretic Peptide Levels and In-Hospital Mortality in Acute Decompensated Heart Failure. J Am Coll Cardiol 49: 1943-1950 [Abstract] [Full Text]  
• Jourdain, P., Jondeau, G., Funck, F., Gueffet, P., Le Helloco, A., Donal, E., Aupetit, J. F., Aumont, M. C., Galinier, M., Eicher, J. C., Cohen-Solal, A., Juilliere, Y. (2007). Plasma Brain Natriuretic Peptide-Guided Therapy to Improve Outcome in Heart Failure: The STARS-BNP Multicenter Study. J Am Coll Cardiol 49: 1733-1739 [Abstract] [Full Text]  
• Rose, R. A., Hatano, N., Ohya, S., Imaizumi, Y., Giles, W. R. (2007). C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor-mediated signalling. J. Physiol. 580: 255-274 [Abstract] [Full Text]  
• Forfia, P. R., Lee, M., Tunin, R. S., Mahmud, M., Champion, H. C., Kass, D. A. (2007). Acute Phosphodiesterase 5 Inhibition Mimics Hemodynamic Effects of B-Type Natriuretic Peptide and Potentiates B-Type Natriuretic Peptide Effects in Failing But Not Normal Canine Heart. J Am Coll Cardiol 49: 1079-1088 [Abstract] [Full Text]  
• Liang, F., O'Rear, J., Schellenberger, U., Tai, L., Lasecki, M., Schreiner, G. F., Apple, F. S., Maisel, A. S., Pollitt, N. S., Protter, A. A. (2007). Evidence for Functional Heterogeneity of Circulating B-Type Natriuretic Peptide. J Am Coll Cardiol 49: 1071-1078 [Abstract] [Full Text]  
• Naegeli, B., Kurz, D. J., Koller, D., Straumann, E., Furrer, M., Maurer, D., Minder, E., Bertel, O. (2007). Single-chamber ventricular pacing increases markers of left ventricular dysfunction compared with dual-chamber pacing. Europace 9: 194-199 [Abstract] [Full Text]  
• Gardner, D. G., Chen, S., Glenn, D. J., Grigsby, C. L. (2007). Molecular Biology of the Natriuretic Peptide System: Implications for Physiology and Hypertension. Hypertension 49: 419-426 [Full Text]  
• Kasama, S., Toyama, T., Hatori, T., Sumino, H., Kumakura, H., Takayama, Y., Ichikawa, S., Suzuki, T., Kurabayashi, M. (2007). Effects of Intravenous Atrial Natriuretic Peptide on Cardiac Sympathetic Nerve Activity and Left Ventricular Remodeling in Patients With First Anterior Acute Myocardial Infarction. J Am Coll Cardiol 49: 667-674 [Abstract] [Full Text]  
• Feringa, H. H H, Schouten, O., Dunkelgrun, M., Bax, J. J, Boersma, E., Elhendy, A., de Jonge, R., Karagiannis, S. E, Vidakovic, R., Poldermans, D. (2007). Plasma N-terminal pro-B-type natriuretic peptide as long-term prognostic marker after major vascular surgery. Heart 93: 226-231 [Abstract] [Full Text]  
• Heart Protection Study Collaborative Group,*, (2007). N-Terminal Pro-B-Type Natriuretic Peptide, Vascular Disease Risk, and Cholesterol Reduction Among 20,536 Patients in the MRC/BHF Heart Protection Study. J Am Coll Cardiol 49: 311-319 [Abstract] [Full Text]  
• Iglesias, J., Hom, D., Antoniotti, M., Ayoub, S., Levine, J. S. (2006). Predictors of worsening renal function in adult patients with congestive heart failure receiving recombinant human B-type brain natriuretic peptide (nesiritide). Nephrol Dial Transplant 21: 3458-3465 [Abstract] [Full Text]  
• Hashim, S., Li, Y., Anand-Srivastava, M. B. (2006). Small cytoplasmic domain peptides of natriuretic peptide receptor-C attenuate cell proliferation through Gi{alpha} protein/MAP kinase/PI3-kinase/AKT pathways. Am. J. Physiol. Heart Circ. Physiol. 291: H3144-H3153 [Abstract] [Full Text]  
• Taplin, C. E., Cowell, C. T., Silink, M., Ambler, G. R. (2006). Fludrocortisone Therapy in Cerebral Salt Wasting. Pediatrics 118: e1904-e1908 [Abstract] [Full Text]  
• Li, Y., Hashim, S., Anand-Srivastava, M. B. (2006). Intracellular peptides of natriuretic peptide receptor-C inhibit vascular hypertrophy via Gq{alpha}/MAP kinase signaling pathways. Cardiovasc Res 72: 464-472 [Abstract] [Full Text]  
• Windt, W. A.K.M., Eijkelkamp, W. B.A., Henning, R. H., Kluppel, A. C.A., de Graeff, P. A., Hillege, H. L., Schafer, S., de Zeeuw, D., van Dokkum, R. P.E. (2006). Renal Damage after Myocardial Infarction Is Prevented by Renin-Angiotensin-Aldosterone-System Intervention. J. Am. Soc. Nephrol. 17: 3059-3066 [Abstract] [Full Text]  
• Mikkelsen, K. V., Moller, J. E., Bie, P., Ryde, H., Videbaek, L., Haghfelt, T. (2006). Tei index and neurohormonal activation in patients with incident heart failure: Serial changes and prognostic value. Eur J Heart Fail 8: 599-608 [Abstract] [Full Text]  
• Shah, K. B., Inoue, Y., Mehra, M. R. (2006). Amyloidosis and the heart: a comprehensive review.. Arch Intern Med 166: 1805-1813 [Abstract] [Full Text]  
• Roig, E. (2006). Usefulness of neurohormonal markers in the diagnosis and prognosis of heart failure. Eur Heart J Suppl 8: E12-E17 [Abstract] [Full Text]  
• Pitzalis, M. V., Iacoviello, M., Di Serio, F., Romito, R., Guida, P., De Tommasi, E., Luzzi, G., Anaclerio, M., Varraso, L., Forleo, C., Pansini, N. (2006). Prognostic value of brain natriuretic peptide in the management of patients receiving cardiac resynchronization therapy. Eur J Heart Fail 8: 509-514 [Abstract] [Full Text]  
• Machado, R. F., Anthi, A., Steinberg, M. H., Bonds, D., Sachdev, V., Kato, G. J., Taveira-DaSilva, A. M., Ballas, S. K., Blackwelder, W., Xu, X., Hunter, L., Barton, B., Waclawiw, M., Castro, O., Gladwin, M. T., for the MSH Investigators, (2006). N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease.. JAMA 296: 310-318 [Abstract] [Full Text]  
• Rienstra, M., Van Gelder, I. C., Van den Berg, M. P., Boomsma, F., Van Veldhuisen, D. J. (2006). Natriuretic peptides in patients with atrial fibrillation and advanced chronic heart failure: determinants and prognostic value of (NT-)ANP and (NT-pro)BNP. Europace 8: 482-487 [Abstract] [Full Text]  
• Huang, S.-C., Wu, E.-T., Ko, W.-J., Lai, L.-P., Hsu, J., Chang, C.-I., Chiu, I.-S., Wang, S.-S., Wu, M.-H., Lin, F.-Y., Chen, Y.-S. (2006). Clinical Implication of Blood Levels of B-Type Natriuretic Peptide in Pediatric Patients on Mechanical Circulatory Support. Ann. Thorac. Surg. 81: 2267-2272 [Abstract] [Full Text]  
• Wagner, F. D., Buz, S., Zais, H., Stasch, J. P., Hetzer, R., Hocher, B. (2006). Humoral and hemodynamic responses after left ventricular assist device implantation and heart transplantation.. Exp. Biol. Med. 231: 861-864 [Abstract] [Full Text]  
• Bjorklund, E, Jernberg, T, Johanson, P, Venge, P, Dellborg, M, Wallentin, L, Lindahl, B, the ASSENT-2 and ASSENT-PLUS Study Groups, (2006). Admission N-terminal pro-brain natriuretic peptide and its interaction with admission troponin T and ST segment resolution for early risk stratification in ST elevation myocardial infarction. Heart 92: 735-740 [Abstract] [Full Text]  
• da Graca, R. L., Hassinger, D. C., Flynn, P. A., Sison, C. P., Nesin, M., Auld, P. A.M. (2006). Longitudinal changes of brain-type natriuretic Peptide in preterm neonates.. Pediatrics 117: 2183-2189 [Abstract] [Full Text]  
• Sansoe, G., Aragno, M., Mastrocola, R., Cutrin, J. C., Silvano, S., Mengozzi, G., Smedile, A., Rosina, F., Danni, O., Rizzetto, M. (2006). Overexpression of kidney neutral endopeptidase (EC 3.4.24.11) and renal function in experimental cirrhosis. Am. J. Physiol. Renal Physiol. 290: F1337-F1343 [Abstract] [Full Text]