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Previous Volume 339:347-348 July 30, 1998 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The clinical relevance of the conclusion of Monzon et al. (March 26 issue)¹ that patients with multiple melanomas have a germ-line mutation of the CDKN2A gene that predisposes them to melanoma is difficult to ascertain because no information is provided on the incidence of this mutation in patients who do not have multiple primary melanomas or in the normal population. Consequently, the possibility that this mutation is unrelated to the pathogenesis of melanoma has not been excluded.

In any case, the mutation appears to be of minor clinical relevance, even if it is associated with multiple melanomas, . . . [Full Text of this Article]

References

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