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Previous Volume 339:348-349 July 30, 1998 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Abnormal melanocytic nevi are a potent risk factor for sporadic melanoma. In persons with a family history of melanoma, the presence of this phenotype is commonly used to identify candidates for screening and surveillance because their risk of melanoma is believed to be increased. We carried out genotype and phenotype studies in families with germ-line CDKN2 mutations and found that the correlation between having the abnormal-nevus phenotype and actually carrying the mutant gene is so poor that this approach to screening is not tenable.

Clark et al. described two families at increased risk for melanoma¹ in which . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Chaudru, V., Chompret, A., Bressac-de Paillerets, B., Spatz, A., Avril, M.-F., Demenais, F. (2004). Influence of Genes, Nevi, and Sun Sensitivity on Melanoma Risk in a Family Sample Unselected by Family History and in Melanoma-Prone Families. JNCI J Natl Cancer Inst 96: 785-795 [Abstract] [Full Text]  
• Goldstein, A. M., Martinez, M., Tucker, M. A., Demenais, F. (2000). Gene-Covariate Interaction between Dysplastic Nevi and the CDKN2A Gene in American Melanoma-prone Families. Cancer Epidemiol. Biomarkers Prev. 9: 889-894 [Abstract] [Full Text]  
• Bataille, V., Snieder, H., MacGregor, A. J., Sasieni, P., Spector, T. D. (2000). Genetics of Risk Factors for Melanoma: an Adult Twin Study of Nevi and Freckles. JNCI J Natl Cancer Inst 92: 457-463 [Abstract] [Full Text]  
• Kefford, R. F., Newton Bishop, J. A., Bergman, W., Tucker, M. A. (1999). Counseling and DNA Testing for Individuals Perceived to Be Genetically Predisposed to Melanoma: A Consensus Statement of the Melanoma Genetics Consortium. JCO 17: 3245-3251 [Full Text]