FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 339:444-449 August 13, 1998 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Human herpesvirus 8 (HHV-8) is a recently discovered virus that appears to have a pathogenic role in Kaposi's sarcoma, multicentric Castleman's disease, and primary-effusion lymphoma, a distinctive lymphoma that arises within body-cavity effusions.^{1,2,3,4,5,6,7} HHV-8 was originally detected in lesions of Kaposi's sarcoma in patients infected with the human immunodeficiency virus (HIV) but was subsequently found in forms of the tumor that occur in HIV-negative patients.^8,9 Similarly, HHV-8–associated multicentric Castleman's disease occurs predominantly in patients with the acquired immunodeficiency syndrome (AIDS) but also in HIV-negative patients.^5,10,11 These findings suggest a direct causal role of HHV-8 in the development of Kaposi's sarcoma . . . [Full Text of this Article]

Case Report

Methods

Cytologic, Immunophenotypic, and Ultrastructural Studies

Molecular and Karyotypic Analyses

Results

Cytopathological, Genotypic, and Karyotypic Findings

Detection of HHV-8 Latency-Associated Nuclear Antigen

Ultrastructural Studies

Detection of HHV-8 DNA in Archival Tissue Specimens

Discussion

Source Information

From the Department of Pathology (D.J., J.M.G., G.L.W., J.F., J.C.A.) and the Division of Infectious Diseases (M.E.B., K.M.K.), Brigham and Women's Hospital and Harvard Medical School; and the AIDS Research Center, Massachusetts General Hospital and Harvard Medical School (D.T.S.) — all in Boston. Address reprints requests to Dr. Aster at the Department of Pathology, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115.

References

Related Letters:

Appearance of Human Herpesvirus 8 on Electron Microscopy
Orenstein J. M., Herndier B., Aster J. C., Jones D.
Extract | Full Text  
N Engl J Med 1999; 340:62-64, Jan 7, 1999. Correspondence

This article has been cited by other articles:

• Carbone, A., Cesarman, E., Spina, M., Gloghini, A., Schulz, T. F. (2009). HIV-associated lymphomas and gamma-herpesviruses. Blood 113: 1213-1224 [Abstract] [Full Text]  
• Chen, Y.-B., Rahemtullah, A., Hochberg, E. (2007). Primary Effusion Lymphoma. The Oncologist 12: 569-576 [Abstract] [Full Text]  
• Sin, S.-H., Roy, D., Wang, L., Staudt, M. R., Fakhari, F. D., Patel, D. D., Henry, D., Harrington, W. J. Jr, Damania, B. A., Dittmer, D. P. (2007). Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling. Blood 109: 2165-2173 [Abstract] [Full Text]  
• Carbone, A, Gloghini, A, Vaccher, E, Marchetti, G, Gaidano, G, Tirelli, U (2005). KSHV/HHV-8 associated lymph node based lymphomas in HIV seronegative subjects. Report of two cases with anaplastic large cell morphology and plasmablastic immunophenotype. J. Clin. Pathol. 58: 1039-1045 [Abstract] [Full Text]  
• Barbera, A. J., Ballestas, M. E., Kaye, K. M. (2004). The Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 N Terminus Is Essential for Chromosome Association, DNA Replication, and Episome Persistence. J. Virol. 78: 294-301 [Abstract] [Full Text]  
• Aljurf, M. D., Owaidah, T. W., Ezzat, A., Ibrahim, E., Tbakhi, A. (2003). Antigen- and/or immune-driven lymphoproliferative disorders. Ann Oncol 14: 1595-1606 [Full Text]  
• Li, H., Komatsu, T., Dezube, B. J., Kaye, K. M. (2002). The Kaposi's Sarcoma-Associated Herpesvirus K12 Transcript from a Primary Effusion Lymphoma Contains Complex Repeat Elements, Is Spliced, and Initiates from a Novel Promoter. J. Virol. 76: 11880-11888 [Abstract] [Full Text]  
• Sarid, R., Klepfish, A., Schattner, A. (2002). Virology, Pathogenetic Mechanisms, and Associated Diseases of Kaposi Sarcoma-Associated Herpesvirus (Human Herpesvirus 8). Mayo Clin Proc. 77: 941-949 [Abstract]  
• Emond, J.-P., Marcelin, A.-G., Dorent, R., Milliancourt, C., Dupin, N., Frances, C., Agut, H., Gandjbakhch, I., Calvez, V. (2002). Kaposi's Sarcoma Associated with Previous Human Herpesvirus 8 Infection in Heart Transplant Recipients. J. Clin. Microbiol. 40: 2217-2219 [Abstract] [Full Text]  
• Corchero, J. L., Mar, E.-C., Spira, T. J., Pellett, P. E., Inoue, N. (2001). Comparison of Serologic Assays for Detection of Antibodies against Human Herpesvirus 8. CVI 8: 913-921 [Abstract] [Full Text]  
• Perez, C. L., Rudoy, S. (2001). Anti-CD20 Monoclonal Antibody Treatment of Human Herpesvirus 8-Associated, Body Cavity-Based Lymphoma with an Unusual Phenotype in a Human Immunodeficiency Virus-Negative Patient. CVI 8: 993-996 [Abstract] [Full Text]  
• Ballestas, M. E., Kaye, K. M. (2001). Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Mediates Episome Persistence through cis-Acting Terminal Repeat (TR) Sequence and Specifically Binds TR DNA. J. Virol. 75: 3250-3258 [Abstract] [Full Text]  
• Luppi, M., Barozzi, P., Schulz, T. F., Setti, G., Staskus, K., Trovato, R., Narni, F., Donelli, A., Maiorana, A., Marasca, R., Sandrini, S., Torelli, G., Sheldon, J. (2000). Bone Marrow Failure Associated with Human Herpesvirus 8 Infection after Transplantation. NEJM 343: 1378-1385 [Abstract] [Full Text]  
• Luppi, M., Barozzi, P., Santagostino, G., Trovato, R., Schulz, T. F., Marasca, R., Bottalico, D., Bignardi, L., Torelli, G. (2000). Molecular evidence of organ-related transmission of Kaposi sarcoma-associated herpesvirus or human herpesvirus-8 in transplant patients. Blood 96: 3279-3281 [Abstract] [Full Text]  
• Luppi, M., Barozzi, P., Schulz, T. F., Trovato, R., Donelli, A., Narni, F., Sheldon, J., Marasca, R., Torelli, G. (2000). Nonmalignant disease associated with human herpesvirus 8 reactivation in patients who have undergone autologous peripheral blood stem cell transplantation. Blood 96: 2355-2357 [Abstract] [Full Text]  
• Brander, C., Suscovich, T., Lee, Y., Nguyen, P. T., O'Connor, P., Seebach, J., Jones, N. G., van Gorder, M., Walker, B. D., Scadden, D. T. (2000). Impaired CTL Recognition of Cells Latently Infected with Kaposi's Sarcoma-Associated Herpes Virus. J. Immunol. 165: 2077-2083 [Abstract] [Full Text]  
• Orenstein, J. M., Herndier, B., Aster, J. C., Jones, D. (1999). Appearance of Human Herpesvirus 8 on Electron Microscopy. NEJM 340: 62-64 [Full Text]