FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 339:472-474 August 13, 1998 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

New molecular techniques have yielded a battery of potential therapies for many diseases, but the clinical fruits of these methods have not been abundant, in part because in vitro models used for screening often do not duplicate in vivo conditions. For example, in vivo the microvascular wall prevents many intravenous agents with in vitro activity from reaching target cells in the tissue. Moreover, the magic bullet of cancer immunotherapy — antibodies conjugated to a drug or toxin — do not consistently hit their mark, because the bull's-eye on the other side of the vascular endothelium remains largely inaccessible to the . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Testa, J. E., Chrastina, A., Oh, P., Li, Y., Witkiewicz, H., Czarny, M., Buss, T., Schnitzer, J. E. (2009). Immunotargeting and cloning of two CD34 variants exhibiting restricted expression in adult rat endothelia in vivo. Am. J. Physiol. Lung Cell. Mol. Physiol. 297: L251-L262 [Abstract] [Full Text]  
• Li, Y., Yu, J., Wang, Y., Griffin, N. M., Long, F., Shore, S., Oh, P., Schnitzer, J. E. (2009). Enhancing Identifications of Lipid-embedded Proteins by Mass Spectrometry for Improved Mapping of Endothelial Plasma Membranes in Vivo. Mol. Cell. Proteomics 8: 1219-1235 [Abstract] [Full Text]  
• Hu, H., Ran, Y., Zhang, Y., Zhou, Z., Harris, S. J., Yu, L., Sun, L., Pan, J., Liu, J., Lou, J., Yang, Z. (2009). Antibody Library-based Tumor Endothelial Cells Surface Proteomic Functional Screen Reveals Migration-stimulating Factor as an Anti-angiogenic Target. Mol. Cell. Proteomics 8: 816-826 [Abstract] [Full Text]  
• Campochiaro, P. A., the First ARVO/Pfizer Institute Working Group, (2006). Ocular versus Extraocular Neovascularization: Mirror Images or Vague Resemblances. IOVS 47: 462-474 [Full Text]  
• Valadon, P., Garnett, J. D., Testa, J. E., Bauerle, M., Oh, P., Schnitzer, J. E. (2006). Screening phage display libraries for organ-specific vascular immunotargeting in vivo. Proc. Natl. Acad. Sci. USA 103: 407-412 [Abstract] [Full Text]  
• Akiyama, H., Mohamedali, K. A., e Silva, R. L., Kachi, S., Shen, J., Hatara, C., Umeda, N., Hackett, S. F., Aslam, S., Krause, M., Lai, H., Rosenblum, M. G., Campochiaro, P. A. (2005). Vascular Targeting of Ocular Neovascularization with a Vascular Endothelial Growth Factor121/Gelonin Chimeric Protein. Mol. Pharmacol. 68: 1543-1550 [Abstract] [Full Text]  
• Hilbe, W, Dirnhofer, S, Oberwasserlechner, F, Schmid, T, Gunsilius, E, Hilbe, G, Woll, E, Kahler, C M (2004). CD133 positive endothelial progenitor cells contribute to the tumour vasculature in non-small cell lung cancer. J. Clin. Pathol. 57: 965-969 [Abstract] [Full Text]  
• Dowlati, A., Robertson, K., Cooney, M., Petros, W. P., Stratford, M., Jesberger, J., Rafie, N., Overmoyer, B., Makkar, V., Stambler, B., Taylor, A., Waas, J., Lewin, J. S., McCrae, K. R., Remick, S. C. (2002). A Phase I Pharmacokinetic and Translational Study of the Novel Vascular Targeting Agent Combretastatin A-4 Phosphate on a Single-Dose Intravenous Schedule in Patients with Advanced Cancer. Cancer Res. 62: 3408-3416 [Abstract] [Full Text]  
• McIntosh, D. P., Tan, X.-Y., Oh, P., Schnitzer, J. E. (2002). Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: A pathway to overcome cell barriers to drug and gene delivery. Proc. Natl. Acad. Sci. USA 99: 1996-2001 [Abstract] [Full Text]  
• MURCIANO, J. C., WIN HARSHAW, D., GHITESCU, L., DANILOV, S. M., MUZYKANTOV, V. R. (2001). Vascular Immunotargeting to Endothelial Surface in a Specific Macrodomain in Alveolar Capillaries. Am. J. Respir. Crit. Care Med. 164: 1295-1302 [Abstract] [Full Text]  
• Christofidou-Solomidou, M., Pietra, G. G., Solomides, C. C., Arguiris, E., Harshaw, D., Fitzgerald, G. A., Albelda, S. M., Muzykantov, V. R. (2000). Immunotargeting of glucose oxidase to endothelium in vivo causes oxidative vascular injury in the lungs. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L794-L805 [Abstract] [Full Text]