Acute Lymphoblastic Leukemia

doi:10.1056/NEJM199808273390907

Volume 339:605-615		August 27, 1998		Number 9

Acute Lymphoblastic Leukemia

Ching-Hon Pui, M.D., and William E. Evans, Pharm.D.

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Acute lymphoblastic leukemia (ALL) is diagnosed in 3000 to 4000persons in the United States each year; two thirds of them arechildren.¹^,² The current rate of cure of nearly 80 percent inchildren attests to remarkable progress in the development ofeffective treatments for resistant subtypes of the disease.Progress has been incremental, from the introduction of combinationchemotherapy and central nervous system treatment for presymptomaticleukemia to newer, intensive treatment regimens for patientsat high risk for relapse (Figure 1). In contrast, only 30 to40 percent of adults with ALL are cured.²^,³ This discrepancycan . . . [Full Text of this Article]

Biologic Characterization of Leukemic Cells

Risk Assessment

Supportive Care

Treatment

Induction of Remission

Intensification (Consolidation) Therapy

Continuation Treatment

Therapy Directed toward the Central Nervous System

Allogeneic Stem-Cell Transplantation

Late Sequelae

Future Considerations

Source Information

From St. Jude Children's Research Hospital (C.-H.P., W.E.E.) and the Colleges of Medicine (C.-H.P., W.E.E.) and Pharmacy (W.E.E.), University of Tennessee, Memphis.

Address reprint requests to Dr. Pui at St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-0318.

References

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