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Correspondence
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Volume 340:65-66 January 7, 1999 Number 1
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Data Bases of Clinical Trials

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To the Editor: In the past 15 years, the medical community has seen the publication of reports on large, randomized clinical trials that have had a substantial effect on the practice of medicine. The design, execution, and analysis of these trials is the province of many outstanding investigators, but many such trials are supported by private pharmaceutical houses that have a clear interest in the outcomes. Although the integrity of the investigators ensures that the results have been fairly presented, pharmaceutical support creates the appearance of undue influence by those with a vested interest.

One way to mitigate the appearance . . . [Full Text of this Article]


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